Article Text

Experiences and challenges of African traditional medicine: lessons from COVID-19 pandemic
  1. Polydor Ngoy Mutombo1,
  2. Ossy Muganga Julius Kasilo2,
  3. Peter Bai James1,
  4. Jon Wardle1,
  5. Olobayo Kunle3,
  6. David Katerere4,
  7. Charles Wambebe5,
  8. Motlalepula Gilbert Matsabisa6,
  9. Mohammed Rahmatullah7,
  10. Jean-Baptiste Nikiema8,
  11. Immaculee Mukankubito9,
  12. Rick Sheridan10,
  13. Rokia Sanogo11,
  14. Veeranoot Nissapatorn12,
  15. Chaisith Sivakorn13,
  16. Satyajit Tripathy6,
  17. Ramesh Goyal14,
  18. Mahaveer Dhobi14
  1. 1Faculty of Health, National Centre for Naturopathic Medicine, Southern Cross University, Lismore, New South Wales, Australia
  2. 2Universal Health Coverage Life Course Cluster, World Health Organization Regional Office for Africa, Brazzaville, Congo
  3. 3Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development, Abuja, Federal Capital Territory, Nigeria
  4. 4Pharmaceutical Science, Tshwane University of Technology, Pretoria, South Africa
  5. 5Pharmacology & Therapeutics, School of Biomedical Sciences, International Biomedical Research Institute (IBRI), Abuja, Nigeria
  6. 6Pharmacology, University of the Free State, Bloemfontein, Free State, South Africa
  7. 7Biotechnology & Genetic Engineering, University of Development Alternative, Dhaka, Bangladesh
  8. 8Medicines Supply, Health Infrastructure and Equipment Maintenance (MIM) Unit, Universal Health Coverage/Life Course Cluster, World Health Organization Regional Office for Africa, Brazzaville, Congo
  9. 9Medicines Supply, Health Infrastructure and Equipment Maintenance (MIM) Unit, World Health Organization Regional Office for Africa, Brazzaville, Congo
  10. 10EMSKE Phytochem, Nairobi, Kenya
  11. 11Médecine Traditionnelle, Institut National de Recherche en Sante Publique, Bamako, Mali
  12. 12School of Allied Health Sciences and World Union for Herbal Drug Discovery (WUHeDD), Walailak University, Thai Buri, Thailand
  13. 13Intensive Care Unit, University College London Hospitals NHS Foundation Trust, London, UK
  14. 14School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, Delhi, India
  1. Correspondence to Dr Polydor Ngoy Mutombo; polydorngoymutombo{at}


Management of COVID-19 in Africa is challenging due to limited resources, including the high cost of vaccines, diagnostics, medical devices and routine pharmaceuticals. These challenges, in addition to wide acceptability, have resulted in increased use of herbal medicines based on African traditional medicines (ATMs) by patients in Africa. This is in spite of the often-significant gaps in evidence regarding these traditional medicines as to their efficacy and safety for COVID-19. African scientists, with some support from their governments, and guidance from WHO and other bodies, are addressing this evidence gap, developing and testing herbal medicines based on ATMs to manage mild-to-moderate cases of COVID-19. Such efforts need further support to meet public health needs.

  • COVID-19
  • Public Health
  • Treatment
  • Health policy
  • Pharmacology

Data availability statement

No data are available.

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Summary box

  • African traditional medicines (ATMs) or therapies are widely used on the continent to meet healthcare needs because of ease of access, low cost and cultural acceptance. However, there is a paucity of clinical evidence on their safety, efficacy and quality to support their use in general. As a result of the COVID-19 pandemic, there was increased use of ATMs as people tried to protect themselves and their families.

  • The WHO issued position statements acknowledging the importance of traditional medicine, established a Regional Expert Advisory Committee on Traditional Medicine for COVID-19 Response, strengthened the capacity of experts and researchers through a series of regional consultations on the contribution of traditional medicine to COVID-19 and is providing technical support and guidance for clinical testing of ATMs.

  • This paper highlights some of the ATM-based interventions that were used and identifies the obstacles to the integration/mainstreaming of traditional medicines proposed for COVID-19 as the absence or paucity of clinical data on the safety, efficacy and quality as well as the lack of resources (human and financial) for robust clinical trials.

  • There is a need for resources to be invested in mainstreaming ATMs as part of pandemic preparedness and response in Africa given the low access to, and high cost of, vaccines and conventional medicines. Such resources would include building and strengthening the capacity of researchers and clinicians to conduct research into plant-based remedies, capacitating national regulatory authorities, increased funding of clinical research to validate medicinal claims.

  • There is a need to create collaboration between conventional and traditional healthcare workers so that there is complementarity to the benefit of African patients.

  • This paper aims to draw attention how ATMs can be mainstreamed by conducting appropriate clinical testing and providing adequate regulation to ensure that good quality, safe and efficacious remedies are promoted. Additionally, this will build and maintain trust in traditional health workers.


Since the emergence of COVID-19 in China in 2019, the health, social and economic impacts of the disease have been felt across the globe. While there has been rapid and unprecedented progress in development of vaccines and new therapies, access to these products in sub-Saharan Africa is constrained. Global therapeutics and vaccine inequities and the emergence of new variants have created challenges in controlling COVID-19 across the African continent.1–5

Thus, in considering Africa’s pandemic preparedness, it is important to understand and learn from, the current experiences from COVID-19. At the onset of COVID-19, there was general concern about how Africa would manage the pandemic given its limited resources, and poorly developed and fragile healthcare systems.6 7 The balance between protecting livelihoods while managing the pandemic with non-pharmacological measures such as lockdowns and social distancing; was also of concern, and debate still rages on the effectiveness of the latter and long-term impact of the former.8 COVID-19 disease management was largely limited to supportive treatment for symptomatic cases, with severe cases more likely to have higher mortality due to the lack of specialised care and access to basic treatments such as corticosteroids, antibiotics, oxygen and ventilators.9

With limited access to conventional health products and amid a deadly global pandemic, some Africans turned to the use of traditional therapies such as herbal medicines, one of the few therapies to which they had easy access. This is not unprecedented, as the use of traditional medicines in Africa has been reported recently for patients with AIDS symptoms in Malawi, South Africa, Uganda and Zimbabwe and as the main source of healthcare for mental illnesses in Uganda.10 Due to the high proportion of patients using herbal medicines (as high as 70% in Ghana for example), some health facilities have initiated the use of herbal medicines as a component of healthcare delivery.10 11 More recently, in the context of infectious diseases with some similarity to COVID-19, Ebola survivors in West Africa appeared to turn to herbal medicines not only for treatment but also to fill the gaps in conventional healthcare services.12

The practice of traditional medicine has always been popular in Africa though it remains largely sidelined from the formal healthcare system for various reasons, chief among them being the paucity of data on the safety, efficacy and quality of most medicinal plants; stigmatisation due to poor perceptions and attitudes; inadequate efforts to conserve medicinal plants and Indigenous knowledge; modernisation; exploitation of communities that own the knowledge; the history of colonialism and secrecy in traditional medicine practices with few reports or documentations of adverse reactions.10 However, the future of African traditional medicines (ATMs) is bright if viewed in the context of service provision, an increase of healthcare coverage, economic potential and poverty reduction. Formal recognition and integration of traditional medicine into conventional medicine will ensure a promising future.

Due to the increased health needs and largely unknown nature of COVID-19, the WHO and its partners called on African scientists to urgently accelerate research and development (R&D) of traditional medicines for COVID-19.13 14

ATM-based therapies in the management of COVID-19 in Africa

ATMs can complement healthcare systems if they are proven to be safe, effective and of high quality through R&D, a process that has been completed for malaria, HIV/AIDS, diabetes, hypertension and sickle-cell disease.15 16 Such advancement in R&D has resulted in more than 40 herbal medicines being included in national essential medicines lists across the WHO-AFRO region.17 In the absence of curative conventional medicines for COVID-19, most African communities in Eastern,18 Southern and West Africa, reported wide use and perceived high efficacy of traditional medicines to prevent and treat suspected symptoms of COVID-19.19 These were generally obtained from preparations that were indicated in traditional African medicine systems for ‘respiratory diseases’ with antiviral, anti-inflammatory, antioxidant, antipyretic, immunomodulatory and cytoprotective properties. Early research appeared to support the potential of African medicinal plants. For example, investigators in Nigeria reported at least a hundred indigenous medicinal plants with potential therapeutic value in the treatment of COVID-19 based on their antiviral, anti-inflammatory, antioxidant, antipyretic, immunomodulatory and cytoprotective properties.20 21 The herbal medicines were used alone or combined with public health recommendations, and were relatively easy to use. The oral route was the most common means of administration, with the most commonly used plants being spices such as cinnamon, clove, garlic, ginger, lemon and leaves of plants such as eucalyptus, guava, lemon, lemongrass, local mint plant and neem. The most commonly reported parts used for herbal medicine were seeds, followed by leaves.

In addition, inhalation of vapour produced by boiling a combination of plant parts or spices while covered up with cloth was also used as a means of administration of herbal medicines for COVID-19 in several countries such as Tanzania, Zambia and Uganda.18 22

In some countries, shea butter was applied on the nose of children to relieve congestion.22 Other herbal medicines used include onion (Ghana), honey mixed with plants (Algeria) and lemon leaves (Mali).22 23

This flexibility, accessibility and relative ease of administrative options resulted in high utilisation of ATMs. A study conducted in Ethiopia, for example, indicated that almost half (46.2%) of the participants used traditional medicines to prevent and treat COVID-19 cases.24 This finding mirrored results globally—in Hong Kong, for example, 44% of the surveyed participants were found to have practised traditional medicines to prevent and treat COVID-19.25

With fewer resources to contain the spread of COVID-19 in Africa, the potential for new variants and endemicity, and underlying support for integration, there is a strong case for enhanced R&D of ATMs-derived herbal medicines for the prophylactic and therapeutic management of the disease, particularly as a complementary treatment measure.13 14 The results of early scientific examination suggest, for example, that traditional medicines from ATMs and other traditions can be effective as adjuvant symptomatic treatment for some clinical manifestations of COVID-19.26 Reverse pharmacology approach to investigate medicinal plants used in ATMs with putative anti-viral properties could serve to identify new preventive and therapeutic agents for inhibition of SARS-CoV-2 and the treatment of COVID-19. Ethnopharmacological evidence highlights the extensive use of specific medicinal plants for COVID-19-like symptoms by certain ethnic groups in Africa, which may assist with identifying candidate medicinal plants or plant recipes for further R&D.27 Results may have regional or even global significance, as there is anecdotal evidence suggesting that some traditional medicines are effective across various diseases and sociocultural contexts.28 29 The shared flora between Africa and other continents with similar cross-cultural therapeutic uses may further help refine potential resources for examination.29 For example, Zingiber officinale (ginger), which is found in Africa is used in the traditional medicine systems of Bangladesh30 and Thailand31 for the symptomatic treatment of COVID-19.

Several ATMs-based therapies are undergoing evaluation for their role in the treatment/management of COVID-19, including clinical trials by scientists.32 Clinical trials of herbal medicines as adjuncts in the treatment of COVID-19 are either completed or ongoing in Burkina Faso, the Democratic Republic of Congo (DRC), Ghana, Guinea, Madagascar, Nigeria (which has the only privately funded study), South Africa, United Republic of Tanzania and Uganda, while clinical observational studies were conducted in Benin, Burkina Faso, Congo and DRC.33 In South Africa and Tanzania, multicentre clinical trials of herbal medicines are ongoing. In some countries such as DRC, Guinea, Madagascar and Uganda, some of these products have received marketing authorisation.

Benefits and challenges associated with the use of ATMs

The easy access to ATMs by most Africans, regardless of demographic and socioeconomic status,10 34 35 is largely due to its affordability and roots in the culture of the people. Such attributes make it a potentially valuable component of the healthcare system, especially in responding to health emergencies, as with the COVID-19 pandemic. Studies have also shown that traditional health practitioners (THPs) are more accessible to the populace with a significantly higher proportion of THPs (1:500 persons) than conventional medical practitioners (1:40 000 persons).35 Further, Africa has high biodiversity, which enriches the materia medica of the continent with over 5000 of the 40 000–45 000 000 known plant species found on the African continent, believed to have medicinal properties.36 Studies have indicated that some of these plant species might have a role in managing COVID-19 (online supplemental table 1) due to their antiviral activities and its associated symptoms (online supplemental table 2). In some African countries, the use of these herbal medicines is reported to have been useful in the early management of the pandemic before the introduction of standard treatment guidelines.

Supplemental material

Despite the abundant natural resources and the anecdotal value of traditional medicine, ATMs remains under-represented and underused in conventional health settings in Africa,26 as demonstrated during the pandemic. While there are several reasons for this,11 37 in the course of the COVID-19 pandemic, the challenges observed include widely publicised unsubstantiated claims of therapeutic activity, insufficient preclinical data, lack of clinical data to validate ethnobotanical claims and insufficient regulatory oversight.38 Therefore, research needs to be directed at addressing these issues, especially the generation of clinical data to validate the use, while regulatory capacity should be strengthened. In addition, ethical and regulatory requirements for approval of national clinical trial protocols across Africa should be harmonised by the WHO.

The absence of a two-way referral system and linkage between ATMs and conventional health systems in most African nations creates mistrust between the two systems to the detriment of patients. As a result, most patients may not disclose ATMs use, thus increasing the potential for adverse reactions and the possibility of delayed diagnosis, among other risks.39 40 The unregulated status of many THPs and their medicines also creates accountability gaps increasing the potential for sub-standard and counterfeit products, professional malpractice and unethical conduct.

While there are ongoing efforts at undertaking the necessary research to validate the claims of efficacy of ATMs derived herbal medicines for COVID-19, they are hampered by the fact that many of the governments in these countries cannot afford to invest adequate financial resources to conduct phase III clinical trials. Second, the substantial reduction in the number of COVID-19 patients has made it difficult to obtain the sample size adequate to obtain robust data on the safety and efficacy of required to validate therapeutic claims according to universally accepted standards. Multicentre and multicountry clinical trials can be a way of addressing this challenge. The WHO, Africa CDC, the African Union Commission and the international community should jointly support countries fast track R&D and mobilise financial resources so that the products confirmed to be safe, efficacious and quality-assured (category 3 herbal medicines) can be locally manufactured and commercialised regionally and internationally.

Lessons learnt from the pandemic

The recourse to the use of ATMs in the early days of the pandemic in Africa demonstrated its continued acceptance by the general public. The poor documentation and validation of the claimed therapeutic value of the ATMs-derived herbal medicines limited their value in the fight against the pandemic. There is an urgent need to encourage and provide the resources needed for continuous research into ATMs-based herbal medicines with a view to provide necessary safety and efficacy data. This is particularly important for infectious disease outbreaks, where traditional medicines are often embraced enthusiastically by the public, and research demonstrates a potential role only after the acute phase.41 Strategies should therefore be implemented to maintain the enthusiasm that resulted in the provision of resources by most African governments for the study of herbal medicines for COVID-19 during the pandemic.

The pace of R&D of herbal medicines will be enhanced by the establishment of consortia of researchers, the private sector and state institutions. In addition, regional collaborations will provide better access to resources and clinical trial participants to achieve the needed statistical power for studies.

There is a need to urgently strengthen the capacity of the National Regulatory Authorities and Ethics review committees to effectively and efficiently regulate the development and use of herbal medicines.

Contribution of WHO to the development of ATMs for COVID-19

The WHO, in acknowledgement of the potential value of ATMs, is collaborating with partners to encourage and guide the development of ATMs for COVID-19 while alerting of the dangers of using non-approved herbal remedies without clinical evidence of their safety, efficacy and quality.42

In collaboration with Africa Centers for Disease Control and Prevention (Africa CDC) and the African Union Commission (AUC) for Social Affairs, WHO set up a Regional Expert Advisory Committee on traditional medicine for COVID-19 Response (REACT) as a coordinating mechanism to elevate the standards of R&D through the pooling of expertise across the African continent for multicentre studies. Membership of the Committee which comprises country experts in various disciplines related to clinical trials on traditional medicines-based therapies includes the Africa Academy of Sciences and African scientists within the EDCTP (European & Developing Countries Clinical Trials Partnership).

As a demonstration of its support for the use of scientifically proven ATMs in the management of COVID-19, WHO, in collaboration with Africa CDC and the European and Developing Countries Clinical Trial Partnership (EDCTP), developed the standard protocols for the randomised, double-blind placebo-controlled phase III multicentre clinical trials to evaluate the safety and efficacy of herbal medicine compared with the standard of care for the treatment of hospitalised patients with mild-to-moderate cases of COVID-19; as well as a protocol for Clinical Observational Studies for preliminary assessment of the safety and efficacy of herbal medicines for the treatment of mild to moderate cases of COVID-19. The committee endorsed the protocols and charter for establishing the data and safety monitoring board, which the WHO Ethics Review Committee and the other relevant Ethics Committees and National Regulatory Authorities subsequently approved at regional and national levels.

A series of regional consultations organised by the WHO during 2020–2022 have encouraged experience sharing by countries in areas such as: Preclinical safety and efficacy studies of ATMs; Ethical and regulatory requirements for approvals and conditional registration of herbal medicines for clinical trials of COVID-19; Clinical trials of ATMs for COVID-19; and Requirements of local manufacturing and good manufacturing practices.

WHO, Africa CDC and African Union continued to work together to harmonise the process for joint support to countries for conducting the clinical trials. Joint field missions composed of WHO, REACT, Africa CDC/AUC and EDCTP to monitor clinical trials of ATMs for COVID-19 were conducted.

Several informal and formal meetings of REACT held between 2020 and 2022, which culminated in the meeting on fast-tracking R&D of ATMs for COVID-19 and local manufacturing of herbal medicines convened by WHO in July 2022, resulted in the development of the criteria for selecting proposed COVID-19 traditional medicines that could be fast-tracked for R&D and local manufacturing. The REACT developed terms of reference for the selection of centres of excellence and hubs for the R&D and local manufacturing of herbal medicines in Africa as well as strategies to mobilise resources for fast-tracking R&D and local manufacturing of herbal medicines.


The devastating nature of COVID-19 forced countries to reconsider the resilience, capacity and available infrastructure of their health systems. Some countries employed innovative and unconventional interventions agents. In Africa and some parts of Asia, this has led to a repurposing of herbal medicines since traditional medical practice is already widely accepted and trusted in those regions. For instance, in Bangladesh and Thailand similar medicinal plants have been repurposed to combat COVID-19. An example is Andrographis paniulata, known locally in Thailand as ‘Fah Talai Jone’ has been used to treat COVID-19 in both Thailand and Indian traditional medicine systems.43 Also, Z. officinale is used in folk medicine of Bangladesh and Thailand for symptomatic treatment of COVID-19.30 31 These examples strongly suggest traditional systems of medicine of other regions need to be considered and harnessed to facilitate drug discovery and development to tread COVID-19.

There was also widespread political support for such practices by African governments in the face of their populations’ low access to vaccines and conventional pharmaceuticals. However, few governments could mobilise resources for the relevant laboratory infrastructure to enable testing of the remedies people were using. Thus, while the potential contribution of ATMs to the COVID-19 response cannot be ignored, its credibility hinges on research to validate its use and establish the efficacy and safety of the products which are touted as being useful. To do this requires a strategy that provides resources to researchers, creates mutually beneficial collaborations between THPs and researchers and the active involvement of regulators in directing what needs to be done.

It is evident that African scientists collaborating with WHO and other bodies are addressing this evidence gap, developing and testing herbal medicines to manage mild to moderate cases of COVID-19, though such efforts need further support to meet public health needs. Some early reports from preclinical safety and efficacy studies on ATMs have been encouraging. However, more funding for larger clinical trials is required to complete the evaluation that would provide evidence to inform clinical use. Collaborations between biomedical scientists, THPs and the private sector are critical to achieving this goal. Several research challenges in this field have been identified by African researchers, including limited funding for phase III clinical research, lack of involvement of knowledge holders (healers) and lack of implementation of enabling policies around mainstreaming ATMs and intellectual property and Indigenous knowledge protection and governance. Other challenges unrelated to resources include laborious administrative processes required by national ethics committees and national regulatory authorities to process clinical trial research protocols for ATMs can delay the research results of ATMs.

Mistrust between THPs, conventional medical practitioners and scientists remains a barrier to mainstreaming, product development and testing ATMs. Furthermore, the lack of specific training in ATMs in many academic and health institutions may reduce the potential for the inclusion of ATMs in scientific and research agendas.

To fully develop and exploit the potential of ATMs in the fight against COVID-19 and other priority diseases, African governments must take ownership of the development process and facilitate the building of a robust industry and attract private investment. This can be achieved by prioritising strengthening of research capacity in the national budgets of African countries. ATMs should also be explicitly included in national research strategies with aggressive fund mobilisation. It is only when ATMs products can be commercialised regionally, and internationally that they can gain global acceptance.

The COVID-19 pandemic has resulted in increased appreciation and use of ATMs and demonstrates the wide acceptability and confidence in its usefulness. In preparing for the next pandemic, given its wide acceptance and popularity, it is important to position ATMs to better serve as part of the response mechanism.

It is obvious that the infrastructure and attention set up in response to the challenges brought by the COVID-19 pandemic, would be equally suitable to other African health priority areas, where lack of adequate research capacity into ATMs derived herbal medicines has hampered development.

We conclude that traditional medicines can complement conventional pharmaceuticals in a time of crisis if they are proven to be proven to be safe and efficacious. The integration of such therapies is explicitly promoted in the Alma Ata declaration in 1978 and reaffirmed—and further expanded on—by the Astana Declaration of Primary Health Care in 2018. This will, however, require the generation of robust scientific data from well-designed studies. There is a need for the development of new protocols, modification of existing ones, or the endorsement of appropriate existing protocols to ensure integration is done in a way that maximises the potential benefits of ATMs while minimising the risks of inappropriate promotion and misuse. The protocols developed by the WHO Regional Office for Africa specifically for testing ATMs for clinical efficacy in COVID-19 are a useful tool in this regard.

Data availability statement

No data are available.

Ethics statements

Patient consent for publication


Special thanks to Maria de Lourdes PEREIRA from the CICECO-Aveiro Institute of Materials & Department of Medical Sciences, University of Aveiro, Aveiro, Portugal; Arletha W. LIVINGSTON from the Innovation Learning Laboratory for Population Health, Morehouse School of Medicine; Rianasoambolanoro RAKOTOSAONA from the Ecole Supérieure Polytechnique d'Antananarivo and Centre National d'Application de Recherches Pharmaceutiques CNARP, Antananarivo, Madagascar; and Polrat WILAIRATANA from the Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand)


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  • Contributors All coauthors made substantial contribution to the conceptualisation, literature search, writing—original draft, editing and review.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

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