Mucosal associated invariant T (MAIT) cells are evolutionarily conserved T cells that are
restricted by the non-classical MHC-1b molecule, MR1. MAIT cells are selected on …

Introduction Africa contributes little to the biomedical literature despite its high burden of
infectious diseases. Global health research partnerships aimed at addressing Africa …

Abstract Chemokine receptor 7 (CCR 7) mediates leukocyte adhesion and chemotaxis from
peripheral sites of inflammation through lymphatic channels to secondary lymphoid organs …

Mucosal-associated invariant T cells (MAITs) have potent antimicrobial activity and are
abundant in humans (5%–10% in blood). Despite strong evolutionary conservation of the …

NKT and mucosal-associated invariant T (MAIT) cells express semi-invariant TCR and
restriction by nonclassical MHC class Ib molecules. Despite common features, the …

Mucosal-associated invariant T (MAIT) cells are semi-invariant Vα7. 2+ CD161highCD4− T
cells that recognize microbial riboflavin precursor derivatives such as 5-OP-RU presented by …

In this article, we explore the root causes of the imbalance and propose strategies to
formulate equitable global health research partnerships; our comments reflect the …

Human beta-defensins (hBDs) are antimicrobial peptides that have an important role in
innate immune responses at epithelial barriers such as the skin. However, the role that hBDs …

The chemokine receptor CCR7 is a seven-transmembrane domain G-protein-coupled
receptor that facilitates leukocyte migration to regional lymph nodes. Aberrant CCR7 …

Somatic mutations have a role in the pathogenesis of a number of diseases, particularly
cancers. Here we present data supporting a role of mitochondrial somatic mutations in an …