Polypharmacy in the elderly complicates therapy, increases cost, and is a challenge for
healthcare agencies. In the context of the evolving role of the pharmacist, this systematic …

Background Bisphosphonate drugs can be used to prevent and treat osteoporosis and to
reduce symptoms and complications of metastatic bone disease; however, they are …

Skin atrophy is an adverse effect of topical corticosteroids (TCs) which, as an established
non-life-threatening effect, has been poorly reported by trials involving these drugs. Atopic …

Background: Available in-vitro and animal studies indicate that inflammation impacts
cytochromes P450 (CYP) activity via multiple and complex transcriptional and post …

Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS‐CoV‐2) infection, is a severe acute respiratory syndrome with an …

Cytochromes P450 (CYP) are subject to important interindividual variability in their activity
due to genetic and environmental factors and some diseases. Limited human data support …

The use of analgesics is based on the empiric administration of a given drug with clinical
monitoring for efficacy and toxicity. However, individual responses to drugs are influenced …

Adverse drug reactions (ADRs) represent an important risk for patients and have a
significant economic impact on health systems. ADRs are the fifth most common cause of …

We conducted a narrative review of the literature to compare the pharmacological, efficacy
and safety profiles of tapentadol and tramadol, and to assess the clinical interest of …

Apixaban and rivaroxaban are the two most prescribed direct factor Xa inhibitors. With the
increased use of DOACs in real-world settings, safety and efficacy concerns have emerged …