Objectives Locally led health research in low and middle income countries (LMICs) is critical
for overcoming global health challenges. Yet, despite over 25 years of international efforts …

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Background The role of fluid resuscitation in the treatment of children with shock and life-
threatening infections who live in resource-limited settings is not established. Methods We …

The imperative for improving health in the world's poorest regions lies in research, yet there
is no question that low participation, a lack of trained staff, and limited opportunities for data …

Background Plasmodium falciparum malaria is a pressing global health problem. A previous
study of the malaria vaccine RTS, S (which targets the circumsporozoite protein), given with …

Summary Background RTS, S/AS01E is the lead candidate malaria vaccine. We recently
showed efficacy against clinical falciparum malaria in 5–17 month old children, during an …

Background TKM-130803, a small interfering RNA lipid nanoparticle product, has been
developed for the treatment of Ebola virus disease (EVD), but its efficacy and safety in …

Background. The efficacy of bacille Calmette-Guérin (BCG) may be enhanced by
heterologous vaccination strategies that boost the BCG-primed immune response. One …

Objective The objective was to measure the efficacy of the vaccination regimen FFM ME-
TRAP in preventing episodes of clinical malaria among children in a malaria endemic area …

ISARIC aims to reach a global consensus behind collection of harmonised clinical data
linked with biological sampling protocols that are of value to anyone facing future outbreaks …