Differentiated cells can be experimentally reprogrammed back to pluripotency by nuclear
transfer, cell fusion or induced pluripotent stem cell technology. Nuclear transfer and cell …

Patient-specific somatic cell reprogramming is likely to have a large impact on medicine by
providing a source of cells for disease modelling and regenerative medicine. Several …

Citrullination is the post-translational conversion of an arginine residue within a protein to
the non-coded amino acid citrulline. This modification leads to the loss of a positive charge …

Epigenetic memory represents a natural mechanism whereby the identity of a cell is
maintained through successive cell cycles, allowing the specification and maintenance of …

We constructed a novel autonomously replicating gene expression shuttle vector, with the
aim of developing a system for transiently expressing proteins at levels useful for …

How cell fate becomes restricted during somatic cell differentiation is a long-lasting question
in biology. Epigenetic mechanisms not present in pluripotent cells and acquired during …

When transplanted into Xenopus oocytes, the nuclei of mammalian somatic cells are
reprogrammed to express stem cell genes such as Oct4, Nanog, and Sox2. We now …

Background Global surgery has recently gained prominence as an academic discipline
within global health. Authorship inequity has been a consistent feature of global health …

Cell differentiation is remarkably stable but can be reversed by somatic cell nuclear transfer,
cell fusion, and iPS. Nuclear transfer to amphibian oocytes provides a special opportunity to …

Nuclear transfer to oocytes is an efficient way to transcriptionally reprogram somatic nuclei,
but its mechanisms remain unclear. Here, we identify a sequence of molecular events that …