Purpose To update the 2003 American Society of Clinical Oncology technology assessment
on adjuvant use of aromatase inhibitors. Recommendations Based on results from multiple …

Every year, more than 2 million women worldwide are diagnosed with breast or cervical
cancer, yet where a woman lives, her socioeconomic status, and agency largely determines …

Substantial inequalities exist in cancer survival rates across countries. In addition to
prevention of new cancers by reduction of risk factors, strategies are needed to close the …

Background In an open-label, randomized, phase 3 trial, we compared the efficacy and
safety of paclitaxel with that of paclitaxel plus bevacizumab, a monoclonal antibody against …

Background The recurrence score based on the 21-gene breast-cancer assay has been
clinically useful in predicting a chemotherapy benefit in hormone-receptor–positive, human …

Background The 21-gene recurrence score assay is prognostic for women with node-
negative, oestrogen-receptor-positive breast cancer treated with tamoxifen. A low recurrence …

Purpose: To update the 2000 ASCO guidelines on the role of bisphosphonates in women
with breast cancer and address the subject of bone health in these women. Results: For …

Background Inflammation in the tumour microenvironment mediated by interleukin 1β is
hypothesised to have a major role in cancer invasiveness, progression, and metastases. We …

Purpose Positive interim analysis findings from four large adjuvant trials evaluating
trastuzumab in patients with early-stage human epidermal growth factor receptor 2 (HER2) …

Background Breast cancer is the most commonly diagnosed cancer worldwide, and its
burden has been rising over the past decades. In this article, we examine and describe the …