[HTML][HTML] Clinical use of whole genome sequencing for Mycobacterium tuberculosis

AA Witney, CA Cosgrove, A Arnold, J Hinds, NG Stoker… - BMC medicine, 2016 - Springer
Drug-resistant tuberculosis (TB) remains a major challenge to global health and to
healthcare in the UK. In 2014, a total of 6,520 cases of TB were recorded in England, of …

[HTML][HTML] Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum

NJ Garton, SJ Waddell, AL Sherratt, SM Lee… - PLoS …, 2008 - journals.plos.org
Background Tuberculous sputum provides a sample of bacilli that must be eliminated by
chemotherapy and that may go on to transmit infection. A preliminary observation that …

Microarrays Reveal that Each of the Ten Dominant Lineages of Staphylococcus aureus Has a Unique Combination of Surface-Associated and Regulatory Genes

JA Lindsay, CE Moore, NP Day, SJ Peacock… - Journal of …, 2006 - Am Soc Microbiol
Staphylococcus aureus is the most common cause of hospital-acquired infection. In healthy
hosts outside of the health care setting, S. aureus is a frequent colonizer of the human nose …

Dissection of the heat-shock response in Mycobacterium tuberculosis using mutants and microarrays

GR Stewart, L Wernisch, R Stabler… - …, 2002 - microbiologyresearch.org
Regulation of the expression of heat-shock proteins plays an important role in the
pathogenesis of Mycobacterium tuberculosis. The heat-shock response of bacteria involves …

Dissection of ESAT-6 System 1 of Mycobacterium tuberculosis and Impact on Immunogenicity and Virulence

P Brodin, L Majlessi, L Marsollier… - Infection and …, 2006 - Am Soc Microbiol
The dedicated secretion system ESX-1 of Mycobacterium tuberculosis encoded by the
extended RD1 region (extRD1) assures export of the ESAT-6 protein and its partner, the 10 …

Whole genome comparison of Campylobacter jejuni human isolates using a low-cost microarray reveals extensive genetic diversity

N Dorrell, JA Mangan, KG Laing, J Hinds… - Genome …, 2001 - genome.cshlp.org
Campylobacter jejuni is the leading cause of bacterial food-borne diarrhoeal disease
throughout the world, and yet is still a poorly understood pathogen. Whole genome …

Gene expression profile of Mycobacterium tuberculosis in a non-replicating state

DGN Muttucumaru, G Roberts, J Hinds, RA Stabler… - Tuberculosis, 2004 - Elsevier
Mycobacterium tuberculosis is able to persist in the human host for decades in an
apparently dormant state where it is presumed to reside in an hypoxic environment. This can …

Stationary phase gene expression of Mycobacterium tuberculosis following a progressive nutrient depletion: a model for persistent organisms?

T Hampshire, S Soneji, J Bacon, BW James, J Hinds… - Tuberculosis, 2004 - Elsevier
The majority of individuals infected with TB develop a latent infection, in which organisms
survive within the body while evading the host immune system. Such persistent bacilli are …

[HTML][HTML] Causes, factors, and control measures of opportunistic premise plumbing pathogens—A critical review

E Leslie, J Hinds, FI Hai - Applied Sciences, 2021 - mdpi.com
Featured Application This critical review is highly timely and the need of the hour, given the
prolonged and unwanted building closures during the COVID-19 pandemic. Extended water …

A member of the cAMP receptor protein family of transcription regulators in Mycobacterium tuberculosis is required for virulence in mice and controls transcription of …

L Rickman, C Scott, DM Hunt… - Molecular …, 2005 - Wiley Online Library
Deletion of gene Rv3676 in Mycobacterium tuberculosis coding for a transcription factor
belonging to the cAMP receptor protein (CRP) family caused growth defects in laboratory …