Background Malaria control remains a challenge in many parts of the Sahel and sub-Sahel
regions of Africa. Methods We conducted an individually randomized, controlled trial to …

We identified 480 persons with positive thick smears for asexual Plasmodium falciparum
parasites, of whom 454 had positive rapid diagnostic tests (RDTs) for the histidine-rich …

Background Artemisinin-based combination therapy (ACT) was deployed in 2005 as an
alternative to chloroquine and is considered the most efficacious treatment currently …

Background Seasonal malaria chemoprevention (SMC) aims to prevent malaria in children
during the high malaria transmission season. The Achieving Catalytic Expansion of SMC in …

In many parts of the African Sahel and sub-Sahel, where malaria remains a major cause of
mortality and morbidity, transmission of the infection is highly seasonal. Seasonal malaria …

A double blind, randomized, controlled Phase 2 clinical trial was conducted to assess the
safety, immunogenicity, and biologic impact of the vaccine candidate Apical Membrane …

Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened
247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in …

Background Spatial and temporal heterogeneities in the risk of malaria have led the WHO to
recommend fine-scale stratification of the epidemiological situation, making it possible to set …

Background Combination treatments, preferably containing an artemisinin derivative, are
recommended to improve efficacy and prevent Plasmodium falciparum drug resistance. Our …

Background Seasonal malaria chemoprevention (SMC) has shown high protective efficacy
against clinical malaria and severe malaria in a series of clinical trials. We evaluated the …