Vaccination policies have shifted dramatically during COVID-19 with the rapid emergence of
population-wide vaccine mandates, domestic vaccine passports and differential restrictions …

COVID-19 poses an extraordinary threat to global public health and an effective vaccine
could provide a key means of overcoming this crisis. Human challenge studies involve the …

Background Few studies have assessed participant safety in human challenge trials (HCTs).
Key questions regarding HCTs include how risky such trials have been, how often adverse …

HOW COMPLICATED CAN VACCINATING HCP AGAINST COVID-19 BE? On face value,
vaccinating HCP against COVID-19 first sounds simple: healthcare systems will receive …

Development of an effective vaccine is the clearest path to controlling the coronavirus
disease 2019 (COVID-19) pandemic. To accelerate vaccine development, some …

In 2022, students at North American universities with third-dose COVID-19 vaccine
mandates risk disenrolment if unvaccinated. To assess the appropriateness of booster …

This report of the WHO Working Group for Guidance on Human Challenge Studies in COVID-
19 outlines ethical standards for COVID-19 challenge studies. It includes eight Key Criteria …

This Open Access volume provides in-depth analysis of the wide range of ethical issues
associated with drug-resistant infectious diseases. Antimicrobial resistance (AMR) is widely …

This open access book provides an extensive review of ethical and regulatory issues related
to human infection challenge studies, with a particular focus on the expansion of this type of …

The unprecedented speed of delivery of SARS-CoV-2 pandemic vaccines has redefined the
limits for all vaccine development. Beyond the aspirational 100-day timeline for tomorrow's …