Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and elimination

T Bousema, C Drakeley - Clinical microbiology reviews, 2011 - Am Soc Microbiol
Malaria remains a major cause of morbidity and mortality in the tropics, with Plasmodium
falciparum responsible for the majority of the disease burden and P. vivax being the …

Asymptomatic malaria infections: detectability, transmissibility and public health relevance

T Bousema, L Okell, I Felger, C Drakeley - Nature Reviews Microbiology, 2014 - nature.com
Most Plasmodium falciparum infections that are detected in community surveys are
characterized by low-density parasitaemia and the absence of clinical symptoms. Molecular …

Submicroscopic Infection in Plasmodium falciparum-Endemic Populations: A Systematic Review and Meta-Analysis

LC Okell, AC Ghani, E Lyons… - The Journal of infectious …, 2009 - academic.oup.com
Introduction Light microscopy examination of blood slides is the main method of detecting
malaria infection; however, it has limited sensitivity. Low-density infections are most likely to …

Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study

H Reyburn, R Mbatia, C Drakeley, I Carneiro… - Bmj, 2004 - bmj.com
Objective To study the diagnosis and outcomes in people admitted to hospital with a
diagnosis of severe malaria in areas with differing intensities of malaria transmission …

[HTML][HTML] Factors determining the occurrence of submicroscopic malaria infections and their relevance for control

LC Okell, T Bousema, JT Griffin, AL Ouédraogo… - Nature …, 2012 - nature.com
Malaria parasite prevalence in endemic populations is an essential indicator for monitoring
the progress of malaria control, and has traditionally been assessed by microscopy …

[HTML][HTML] Reducing Plasmodium falciparum Malaria Transmission in Africa: A Model-Based Evaluation of Intervention Strategies

JT Griffin, TD Hollingsworth, LC Okell… - PLoS …, 2010 - journals.plos.org
Background Over the past decade malaria intervention coverage has been scaled up across
Africa. However, it remains unclear what overall reduction in transmission is achievable …

[HTML][HTML] Hitting hotspots: spatial targeting of malaria for control and elimination

T Bousema, JT Griffin, RW Sauerwein, DL Smith… - PLoS …, 2012 - journals.plos.org
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[HTML][HTML] Efficacy of RTS, S/AS01E vaccine against malaria in children 5 to 17 months of age

P Bejon, J Lusingu, A Olotu, A Leach… - … England Journal of …, 2008 - Mass Medical Soc
Background Plasmodium falciparum malaria is a pressing global health problem. A previous
study of the malaria vaccine RTS, S (which targets the circumsporozoite protein), given with …

Rapid diagnostic tests compared with malaria microscopy for guiding outpatient treatment of febrile illness in Tanzania: randomised trial

H Reyburn, H Mbakilwa, R Mwangi, O Mwerinde… - Bmj, 2007 - bmj.com
Objective To compare rapid diagnostic tests (RDTs) for malaria with routine microscopy in
guiding treatment decisions for febrile patients. Design Randomised trial. Setting Outpatient …

[HTML][HTML] Genome-wide and fine-resolution association analysis of malaria in West Africa

M Jallow, YY Teo, KS Small, KA Rockett, P Deloukas… - Nature …, 2009 - nature.com
We report a genome-wide association (GWA) study of severe malaria in The Gambia. The
initial GWA scan included 2,500 children genotyped on the Affymetrix 500K GeneChip, and …