Background The Mini Mental State Examination (MMSE) is a cognitive test that is commonly
used as part of the evaluation for possible dementia. Objectives To determine the diagnostic …

This chapter outlines some general issues in searching for studies; describes the main
sources of potential studies; and discusses how to plan the search process, design and …

Systematic reviews are difficult to keep up to date, but failure to do so leads to a decay in
review currency, accuracy, and utility. We are developing a novel approach to systematic …

Post-operative cognitive complications such as delirium have been consistently associated
with poor short and long term outcomes, and the role of anesthesia, particularly the role of …

Background Dementia is a progressive syndrome of global cognitive impairment with
significant health and social care costs. Global prevalence is projected to increase …

New approaches to evidence synthesis, which use human effort and machine automation in
mutually reinforcing ways, can enhance the feasibility and sustainability of living systematic …

Cochrane systematic reviews are conducted and reported according to rigorous standards.
A study flow diagram must be included in a new review, and there is clear guidance from the …

Machine learning (ML) algorithms have proven highly accurate for identifying Randomized
Controlled Trials (RCTs) but are not used much in practice, in part because the best way to …

Background Research suggests that measurable change in cerebrospinal fluid (CSF)
biomarkers occurs years in advance of the onset of clinical symptoms (Beckett 2010). In this …

While it is important for the evidence supporting practice guidelines to be current, that is
often not the case. The advent of living systematic reviews has made the concept of “living …