Abstract
After exposure to a teacher with multidrug-resistant pulmonary tuberculosis, 31 children developed latent infection. Twenty-six were treated with levofloxacin and pyrazinamide. Twelve required a change in therapy secondary to adverse effects. The most common adverse effects included abdominal pain, arthralgias/myalgias and elevated transaminases. All children reported at least 1 adverse effect. Fifteen children completed treatment. All adverse effects were transient.
MeSH terms
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Adolescent
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Antibiotic Prophylaxis / adverse effects
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Antibiotic Prophylaxis / methods*
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Antitubercular Agents / adverse effects
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Antitubercular Agents / therapeutic use*
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Child
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Contact Tracing
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Humans
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Latent Tuberculosis / drug therapy*
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Latent Tuberculosis / epidemiology
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Latent Tuberculosis / microbiology
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Levofloxacin / adverse effects
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Levofloxacin / therapeutic use
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Pyrazinamide / adverse effects
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Pyrazinamide / therapeutic use
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Retrospective Studies
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Tuberculosis, Multidrug-Resistant / drug therapy*
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Tuberculosis, Multidrug-Resistant / epidemiology
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Tuberculosis, Multidrug-Resistant / microbiology
Substances
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Antitubercular Agents
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Pyrazinamide
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Levofloxacin