In an effort to theoretically integrate perspectives of self-care and health promotion, the Health-Promoting Self-Care System Model is proposed as a framework for identifying and explaining sequential patterns among factors which influence the decision-making, performance and outcomes of health-promoting lifestyles. The model is based upon a synthesis of elements comprising constructs of the Self-Care Deficit Nursing Theory as well as certain factors in the Interaction Model of Client Health Behaviour and the Health Promotion Model. Directions for research and practice provided by the model should encourage the development of a cumulative nursing knowledge base and contribute to the goal of enhancing the health and well-being of persons across developmental and sociocultural contexts.