Small randomized trial among low-birth-weight children receiving bacillus Calmette-Guérin vaccination at first health center contact

Pediatr Infect Dis J. 2012 Mar;31(3):306-8. doi: 10.1097/INF.0b013e3182458289.

Abstract

A total of 105 low-birth-weight children presenting for first vaccination were randomized to receive bacillus Calmette-Guérin (BCG) immediately or later (current practice). The mortality rate ratio for BCG was 0.17 (95% CI = 0.02-1.35) within 3 days of enrollment, 0.28 (0.06-1.37) in the first month, and 0.27 (0.07-0.98) after 2 months of age. The mortality rate ratio was 0.41 (0.14-1.18) (P = 0.098) in infancy. Administration of BCG vaccine at first contact may contribute to lower mortality.

Trial registration: ClinicalTrials.gov NCT00146302.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • BCG Vaccine / administration & dosage*
  • BCG Vaccine / immunology*
  • Female
  • Humans
  • Infant
  • Infant Mortality
  • Infant, Low Birth Weight*
  • Infant, Newborn
  • Male
  • Vaccination / methods*

Substances

  • BCG Vaccine

Associated data

  • ClinicalTrials.gov/NCT00146302