Clinical characteristics of patients with tuberculosis-destroyed lung
OBJECTIVE: To define the clinical characteristics of patients with tuberculosis (TB) destroyed lung due to past TB.
DESIGN: We reviewed patients with TB-destroyed lung between May 2005 and June 2011.
RESULTS: A total of 595 patients from 21 hospitals were enrolled. The mean age was 65.63 ± 0.47 (mean ± standard error); 60.5% were male. The mean number of lobes involved was 2.59 ± 0.05. Pleural thickening was observed in 54.1% of the patients. Mean forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC, bronchodilator response and number of exacerbations per year were respectively 2.06 ± 0.03 l (61.26% ± 0.79), 1.16 ± 0.02 l (49.05% ± 0.84), 58.03% ± 0.70, 5.70% ± 0.34, and 0.40 ± 0.04. The number of lobes involved was significantly correlated with FVC and FEV1, and with the number of exacerbations per year. Use of long-acting muscarinic antagonists or long-acting beta-2 agonists plus inhaled corticosteroids resulted in bronchodilatory effects. Multivariable regression analysis showed that age, initial FEV1 (%) and number of exacerbations during follow-up were independent factors affecting change in FEV1.
CONCLUSION: Decreased lung function with exacerbation, and progressive decline of FEV1 were observed in patients with TB-destroyed lung.
Keywords: FEV1; chronic obstructive pulmonary disease; pulmonary function test; tuberculosis-destroyed lung
Document Type: Research Article
Affiliations: 1: Department of Internal Medicine, Seoul St. Mary's Hospital, Catholic University of Korea, Seoul, Korea 2: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea 3: Department of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, Korea 4: Division of Pulmonary and Critical Care Medicine, Kyung Hee Medical Center, Kyung Hee University, School of Medicine, Seoul, Korea 5: Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea 6: Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea 7: Department of Internal Medicine, Hallym University Sacred Heart Hospital, Seoul, Korea 8: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea 9: Department of Internal Medicine, Hanyang University Guri Hospital, Guri, Korea 10: Department of Internal Medicine, Chonbuk National University College of Medicine, Jeonju, Korea 11: Departments of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea 12: Division of Respirology, Department of Internal Medicine, St Carollo Hospital, Seoul, Korea 13: Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 14: Division of Critical Care and Pulmonology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul, Korea 15: Department of Internal Medicine, Bucheon St Mary's Hospital, Catholic University of Korea, Bucheon, Korea 16: Department of Internal Medicine, St Paul's Hospital, Catholic University of Korea, Seoul, Korea 17: Department of Internal Medicine, Yeouido St Mary's Hospital, Catholic University of Korea, Seoul, Korea 18: Department of Internal Medicine, Uijeongbu St. Mary's Hospital, Catholic University of Korea, Seoul, Korea 19: Department of Internal Medicine, Incheon St Mary's Hospital, Catholic University of Korea, Seoul, Korea 20: Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Korea 21: Department of Internal Medicine, Wonkwang University Sanbon Hospital, Gunpo, Korea
Publication date: 01 January 2013
The International Journal of Tuberculosis and Lung Disease (IJTLD) is for clinical research and epidemiological studies on lung health, including articles on TB, TB-HIV and respiratory diseases such as COVID-19, asthma, COPD, child lung health and the hazards of tobacco and air pollution. Individuals and institutes can subscribe to the IJTLD online or in print – simply email us at [email protected] for details.
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