Original ArticleClinical Sepsis in Neonates and Young Infants, United States, 1988-2006
Section snippets
Methods
We used data from the 1988-2006 National Center for Health Statistics’ National Hospital Discharge Survey (NHDS), a representative survey of discharges from the nation’s nonfederal, short-stay hospitals. The NHDS has received approval by the NCHS Research Ethics Review Board. This study using NHDS data did not require separate institutional review board approval. Sampling for this survey uses a multistage approach; discharges are selected at random from a national probability sample of
Results
From 1988 through 2006, there were an estimated 2.5 million (n = 23 086) sepsis hospitalizations in newborns and infants aged <3 months (112 000-146 000 discharges annually), one-third (836 000) of which were in preterm infants (Table I). Nearly 50% of the sepsis hospitalizations in term infants were in the early-onset subgroup. In 2006, the overall sepsis hospitalization rate was 30.8/1000 live births, with a >3-fold higher rate in preterm infants compared with term infants (85.4/1000 preterm
Discussion
Hospitalizations for neonatal sepsis in term infants decreased by approximately 4% annually after issuance of initial IAP guidelines to prevent GBS sepsis. No further decline was observed after issuance of revised IAP guidelines; however, in term infants and the early-onset subgroup, sepsis hospitalization rates were lower during this period compared with the years before issuance of the first IAP guidelines. These findings mirror previously reported trends in invasive early-onset GBS disease
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The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. The authors declare no conflicts of interest.