Letters to the EditorDrug quality, a contributor to drug resistance?
References (3)
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The pill pirates
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Cited by (39)
The role of antimalarial quality in the emergence and transmission of resistance
2018, Medical HypothesesCitation Excerpt :In a 2004 study of artemisinin-based antimalarials (including ACTs) available in Southeast Asia, researchers estimated that 53% did not contain the correct concentration of API [61]. The percentage of the stated amount of API for chloroquine tablets in Nigeria (published 1995) were found to range from 0 to 159% (n = 15), syrups 94 to 126% (n = 15) and injections 106 to 113% (n = 2) [62]. In another study, an analysis of artesunate tablets purchased from Cameroon in 2007 found that the medicine contained chloroquine but no artesunate, and that one packet contained contaminated water [26].
An empirical review of antimalarial quality field surveys: the importance of characterising outcomes
2018, Journal of Pharmaceutical and Biomedical AnalysisCitation Excerpt :In 2010, WHO redefined the substandard medicines as- “pharmaceutical products that do not meet their quality standards and specifications” [15]. Substandard products that lack adequate active pharmaceutical ingredients (API) can have major, and potentially disastrous, implications including, but not exclusive to, the development of disease resistance, impacting the entire population [16–18]. Substandard products are not only limited to those with API content outside the accepted ranges.
Non-prescription antimicrobial use worldwide: A systematic review
2011, The Lancet Infectious DiseasesCitation Excerpt :Duration of antimicrobial use was shorter without than with a prescription.100 Many studies of non-prescription dispensing showed short, often single-day, courses of antimicrobials.41,48,82,85,88,94,101 Dose of antimicrobials was also commonly lower than standard doses.10,41,85,89
Development and validation of a reversed-phase LC method for analysing potentially counterfeit antimalarial medicines
2006, Journal of Pharmaceutical and Biomedical AnalysisRevisiting the blind spot of substandard and fake drugs as drivers of antimicrobial resistance in LMICs
2023, Annals of Medicine and SurgerySubstandard and falsified antibiotics: Neglected drivers of antimicrobial resistance?
2022, BMJ Global Health