Elsevier

Biochemical Pharmacology

Volume 36, Issue 16, 15 August 1987, Pages 2633-2636
Biochemical Pharmacology

The activity of alkyl phosphorylcholines and related derivatives against Leishmania donovani

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Abstract

Several alkyl phosphorylcholines and related derivatives were tested against Leishmania donovani amastigotes in mouse peritoneal macrophages in vitro and ED50 values were determined in the range of 1–12 μM. The three alkyl phosphorylcholines tested against L. donovani in BALB/c mice were active, an Ed50 of 12.8 mg/kg/day × 5 was ascertained for one compound, but an alkyl phosphorylethanolamine was inactive.

References (14)

  • R.A. Neal et al.

    Trans. R. Soc. trop. Med. Hyg.

    (1985)
  • M.L. Ancelin et al.

    Biochem. Pharmac.

    (1985)
  • The Leishmaniases

    WHO Technical Report Series, 701

    (1984)
  • R.A. Neal et al.

    J. Antimub. Chemother.

    (1984)
  • S.L. Croft et al.

    Ann. trop. Med. Parasitol.

    (1985)
  • R. Hirt et al.

    Pharmaceut. acta helvet.

    (1958)
  • S. Tsushima et al.

    Chem. Pharm. Bull.

    (1982)
There are more references available in the full text version of this article.

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