Table 2

HSV-2 epidemiology research progress according to the associated research priorities set in the 2001 WHO HSV-2 workshop

WHO 2001 research priority: HSV-2 epidemiologyHas the priority been addressed?Explanation
HSV-2 prevalence in LMICs Embedded Image
  • 0 studies based in the Middle East, North Africa, Eastern Europe and Western Asia regions.

  • 4 cohort studies of HSV-2 incidence among younger populations (mean age=25 years) in the African regions.

  • HSV-2 prevalence studies among high-risk populations were few, and the majority were in East and South Asia.

HSV-2 as the cause of genital ulcer disease (GUD) aetiology Embedded Image
  • Most studies in South America (n=5)

  • 0 cohort studies to clarify the natural history and transmission of HSV-2.

  • More studies are required to understand contribution of HSV-2 to GUD in LMICs

Aciclovir resistance status in LMICs

Embedded Image
  • Antiviral resistance, including aciclovir, was also highly understudied.

  • 1 study in total.

  • HSV-2, herpes simplex virus type 2; LMICs, low-income and middle-income countries.