N | Unadjusted model | Adjusted model | |||
Zero disutility (%) | Marginal estimate (95% CI) | Zero disutility (%) | Marginal estimate (95% CI) | ||
Child EQ-5D-3L | |||||
Argentina | |||||
iGBS exposed | 13 | 47 | 0.103 (0.048 to 0.167) | 47 | 0.156 (0.080 to 0.239) |
Unexposed | 9 | 65 | 0.061 (0.021 to 0.112) | 65 | 0.120 (0.046 to 0.207) |
India | |||||
iGBS exposed | 35 | 88 | 0.023 (0.007 to 0.046) | 88 | 0.059 (0.014 to 0.120) |
Unexposed | 65 | 94 | 0.010 (0.003 to 0.021) | 94 | 0.036 (0.006 to 0.083) |
Mozambique | |||||
iGBS exposed | 41 | 85.4 | 0.037 (0.017 to 0.063) | 82 | 0.032 (0.011 to 0.061) |
Unexposed | 143 | 92.7 | 0.017 (0.078 to 0.029) | 93 | 0.018 (0.049 to 0.039) |
South Africa | |||||
iGBS exposed | 43 | 85 | 0.035 (0.015 to 0.062) | 86 | 0.077 (0.021 to 0.153) |
Unexposed | 117 | 93 | 0.016 (0.007 to 0.027) | 92 | 0.048 (0.011 to 0.106) |
Overall | |||||
iGBS exposed | 132 | 0.051 (0.031 to 0.074) | 0.082 (0.043 to 0.130) | ||
Unexposed | 334 | 0.027 (0.014 to 0.042) | 0.057 (0.023 to 0.099) | ||
Caregiver EQ-5D-3L | |||||
Argentina | |||||
iGBS exposed | 13 | 25 | 0.153 (0.104 to 0.206) | 28 | 0.179 (0.107 to 0.247) |
Unexposed | 9 | 30 | 0.145 (0.092 to 0.200) | 26 | 0.184 (0.110 to 0.264) |
India | |||||
iGBS exposed | 35 | 55 | 0.105 (0.070 to 0.143) | 58 | 0.172 (0.107 to 0.243) |
Unexposed | 65 | 61 | 0.093 (0.065 to 0.122) | 59 | 0.175 (0.108 to 0.249) |
Mozambique | |||||
iGBS exposed | 42 | 86 | 0.029 (0.015 to 0.047) | 83 | 0.020 (0.008 to 0.038) |
Unexposed | 143 | 89 | 0.024 (0.013 to 0.035) | 89 | 0.020 (0.008 to 0.037) |
South Africa | |||||
iGBS exposed | 43 | 93 | 0.012 (0.004 to 0.024) | 93 | 0.037 (0.009 to 0.078) |
Unexposed | 117 | 95 | 0.010 (0.004 to 0.018) | 94 | 0.036 (0.009 to 0.076) |
Overall | |||||
iGBS exposed | 133 | 0.075 (0.056 to 0.095) | 0.103 (0.068 to 0.141) | ||
Unexposed | 334 | 0.068 (0.051 to 0.086) | 0.105 (0.067 to 0.145) |
Full specification of the zero-inflated beta models and model coefficients are provided in online supplemental tables 7–54. Unadjusted model using pooled data across countries includes covariates for GBS exposure and country. Adjust model using pooled data also includes covariates for age, sex, preterm birth and caregiver highest education.
N in italics is the number of participants in each cohort.
EQ-5D-3L, EuroQol 5-Dimensions-3-Level; iGBS, invasive Group B Streptococcus.