Table 3

Estimated child and caregiver health state disutility valued using time-trade-off among iGBS-exposed versus unexposed participants, by country

NUnadjusted modelAdjusted model
Zero disutility (%)Marginal estimate
(95% CI)
Zero disutility (%)Marginal estimate
(95% CI)
Child EQ-5D-3L
Argentina
 iGBS exposed13470.103 (0.048 to 0.167)470.156 (0.080 to 0.239)
 Unexposed9650.061 (0.021 to 0.112)650.120 (0.046 to 0.207)
India
 iGBS exposed35880.023 (0.007 to 0.046)880.059 (0.014 to 0.120)
 Unexposed65940.010 (0.003 to 0.021)940.036 (0.006 to 0.083)
Mozambique
 iGBS exposed4185.40.037 (0.017 to 0.063)820.032 (0.011 to 0.061)
 Unexposed14392.70.017 (0.078 to 0.029)930.018 (0.049 to 0.039)
South Africa
 iGBS exposed43850.035 (0.015 to 0.062)860.077 (0.021 to 0.153)
 Unexposed117930.016 (0.007 to 0.027)920.048 (0.011 to 0.106)
Overall
 iGBS exposed1320.051 (0.031 to 0.074)0.082 (0.043 to 0.130)
 Unexposed3340.027 (0.014 to 0.042)0.057 (0.023 to 0.099)
Caregiver EQ-5D-3L
Argentina
 iGBS exposed13250.153 (0.104 to 0.206)280.179 (0.107 to 0.247)
 Unexposed9300.145 (0.092 to 0.200)260.184 (0.110 to 0.264)
India
 iGBS exposed35550.105 (0.070 to 0.143)580.172 (0.107 to 0.243)
 Unexposed65610.093 (0.065 to 0.122)590.175 (0.108 to 0.249)
Mozambique
 iGBS exposed42860.029 (0.015 to 0.047)830.020 (0.008 to 0.038)
 Unexposed143890.024 (0.013 to 0.035)890.020 (0.008 to 0.037)
South Africa
 iGBS exposed43930.012 (0.004 to 0.024)930.037 (0.009 to 0.078)
 Unexposed117950.010 (0.004 to 0.018)940.036 (0.009 to 0.076)
Overall
 iGBS exposed1330.075 (0.056 to 0.095)0.103 (0.068 to 0.141)
 Unexposed3340.068 (0.051 to 0.086)0.105 (0.067 to 0.145)
  • Full specification of the zero-inflated beta models and model coefficients are provided in online supplemental tables 7–54. Unadjusted model using pooled data across countries includes covariates for GBS exposure and country. Adjust model using pooled data also includes covariates for age, sex, preterm birth and caregiver highest education.

  • N in italics is the number of participants in each cohort.

  • EQ-5D-3L, EuroQol 5-Dimensions-3-Level; iGBS, invasive Group B Streptococcus.