Table 1

The WHO disease classification and treatment according to severity (extracted from WHO Therapeutics and COVID-19 11th version, dated 14 July 2022)

Non-severeSevereCritical
Disease severityAbsence of signs of severe or critical disease
  • Oxygen saturation <90%

  • Signs of pneumonia

  • Signs of severe respiratory distress

  • Requires life-sustaining treatment

  • Acute respiratory distress syndrome

  • Sepsis

  • Septic shock

Interventions
Strong recommendation in favour
  • Nirmatrelvir and ritonavir

  • Corticosteroids

  • IL-6 receptor blockers or baricitinib (depending on availability as well as clinical and contextual factors)

Weak or conditional recommendations in favour
  • Molnupiravir

  • Sotrovimab

  • Remdesivir

  • Casirivimab and imdevimab*

  • Casirivimab and imdevimab

  • *If rapid viral genotyping is available and confirms infection with a susceptible SARS-CoV-2 variant.