Table 1

Examples of compounds in preclinical development

Inhibitor/compound seriesLead laboratoryEffective in animal modelsStageReferences
Phosphatidylinositol 4-kinaseNovartisYesPhase 1 human trials 15
Bumped kinase inhibitorsUniversity of WashingtonYesPreclinical candidate 26
Lysyl tRNA synthetaseDDU, University of DundeeYesLate lead profiling 13
BenzoxaboroleAnacor, University of VermontYesLate lead profiling 29
SLU-2633/MMV665917St. Louis University, University of VermontYesLate lead profiling 31
Phenylalanine tRNA synthetaseBROAD Institute, University of VermontYesEarly lead profiling 16