(A) Relative incidence ratios (RIR) and interaction effects of the adverse events for all recommended coadministrations studied. (B) RIR and interaction effects of the adverse events for all never recommended coadministrations studied
| Vaccines coadministered | No of vaccines | RIR; (95% CI); p value; interaction | ||||||||
| Fever | Gastrointestinal | General symptoms | Local symptoms | Musculoskeletal | Neurological | Rash | Respiratory/ misc | Sensitivity/ anaphylaxis | ||
| (A) RIR and interaction effects of the adverse events for all recommended coadministrations studied | ||||||||||
| DTaP/IPV or dTaP/IPV+MMR | 2 | 0.76 | 0.76 | 1.24 | 0.42 | 1.09 | 1.12 | 0.78 | 0.87 | 1.00 |
| (0.70 to 0.82) | (0.68 to 0.84) | (0.85 to 1.80) | (0.09 to 1.90) | (0.71 to 1.68) | (0.68 to 1.84) | (0.71 to 0.87) | (0.83 to 0.92) | (0.63 to 1.59) | ||
| 6.57×10−11 | 7.34×10−7 | 0.258 | 0.26 | 0.686 | 0.66 | 2.77×10−6 | 9.85×10−7 | 0.988 | ||
| Inhibitory | Inhibitory | Non-significant | Non-significant | Non-significant | Non-significant | Inhibitory | Inhibitory | Non-significant | ||
| DTaP/IPV/Hib+ MenB+PCV | 3 | 1.25 | 1.29 | 942.2 | 350.8 | 8.38×10+8 | 5.31×10+4 | 0.95 | 1.14 | 0.22 |
| (0.80 to 1.95) | (0.81 to 2.06) | (1.65×10−98 to 5.39×10+103) | (0.00-inf) | (0.00-inf) | (6.13×10−222 to 40.60×10+230) | (0.58 to 1.54) | (0.86 to 1.50) | (0.01 to 4.19) | ||
| 0.333 | 0.282 | 0.954 | 1 | 0.973 | 0.967 | 0.821 | 0.359 | 0.313 | ||
| Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | ||
| DTaP/IPV/Hib+MenC | 2 | 1.51 | 0.74 | 0.78 | 0.33 | 0.91 | 2.48 | 0.94 | 0.8 | 1.29 |
| (1.41 to 1.63) | (0.70 to 0.78) | (0.58 to 1.05) | (0.10 to 1.08) | (0.38 to 2.19) | (1.67 to 3.68) | (0.88 to 0.99) | (0.77 to 0.82) | (0.82 to 2.05) | ||
| < 2×10−16 | < 2×10−16 | 0.103 | 0.067 | 0.83 | 6.5×10−6 | 0.033 | < 2×10−16 | 0.27 | ||
| Amplifying (RI<1) | Inhibitory | Non-significant | Non-significant | Non-significant | Amplifying (RI<1) | Inhibitory | Inhibitory | Non-significant | ||
| DTaP/IPV/Hib+ MenC+PCV | 3 | 1.93 | 1.31 | 1.25 | 13.87 | 1.53×10+5 | 1.44 | 1.49 | 1.27 | 1.68 |
| (1.63 to 2.29) | (1.14 to 1.49) | (0.63 to 2.51) | (0.74 to 260.58) | (2.16×10−121-10.08×10+131) | (0.53 to 3.92) | (1.29 to 1.74) | (1.17 to 1.38) | (0.56 to 5.09) | ||
| 4,77×10−14 | 1.17×10−4 | 0.523 | 0.079 | 0.936 | 0.471 | 1.64×10−7 | 1.15×10−8 | 0.356 | ||
| Amplifying | Amplifying | Non-significant | Non-significant | Non-significant | Non-significant | Amplifying | Amplifying | Non-significant | ||
| DTaP/IPV/Hib+ MenC+ RV | 3 | 0.94 | 1.65 | 0.7 | 1.74×10+7 | 1.47×10−5 | 1.8 | 1.17 | 1.1 | 1.25 |
| (0.69 to 1.28) | (1.35 to 2.02) | (0.20 to 2.38) | (0.00-inf) | (0.00-inf) | (0.20 to 16.08) | (0.94 to 1.44) | (0.98 to 1.24) | (0.11 to 14.68) | ||
| 0.714 | 9.19×10−7 | 0.565 | 0.994 | 0.988 | 0.6 | 0.152 | 0.099 | 0.858 | ||
| Non-significant | Amplifying | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | ||
| DTaP/IPV/Hib+PCV | 2 | 0.74 | 0.75 | 0.8 | 0.14 | 0.87 | 0.95 | 0.74 | 0.82 | 1.26 |
| (0.70 to 0.78) | (0.72 to 0.79) | (0.61 to 1.05) | (0.05 to 0.39) | (0.37 to 2.06) | (0.71 to 1.28) | (0.71 to 0.78) | (0.80 to 0.84) | (0.87 to 1.83) | ||
| < 2×10−16 | < 2×10−16 | 0.103 | 1.45×10−4 | 0.749 | 0.754 | < 2×10−16 | < 2×10−16 | 0.228 | ||
| Inhibitory | Inhibitory | Non-significant | Inhibitory | Non-significant | Non-significant | Inhibitory | Inhibitory | Non-significant | ||
| DTaP/IPV/Hib+PCV+ RV | 3 | 1.44 | 1.16 | 1.31 | 6.29×10−7 | 2.43×10+4 | 0.3 | 1.19 | 1.4 | 0.84 |
| (1.09 to 1.90) | (0.97 to 1.40) | (0.38 to 4.46) | (0.00-inf) | (0.00-inf) | (0.03 to 2.71) | (0.97 to 1.46) | (1.25 to 1.57) | (0.07 to 10.32) | ||
| 0.009 | 0.11 | 0.67 | 0.996 | 0.983 | 0.286 | 0.099 | 1.20×10−8 | 0.893 | ||
| Amplifying | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Amplifying | Non-significant | ||
| DTaP/IPV/Hib+RV | 2 | 1.62 | 0.71 | 0.49 | 0.55 | 1.39×10+4 | 1.6 | 0.82 | 0.80 | 0.90 |
| (1.42 to 1.85) | (0.65 to 0.77) | (0.27 to 0.89) | (0.10 to 3.03) | (2.02×10−107-90.50×10+114) | (0.78 to 3.29) | (0.74 to 0.90) | (0.75 to 0.84) | (0.30 to 2.63) | ||
| 4.36×10−13 | 7.19×10−16 | 0.019 | 0.491 | 0.942 | 0.204 | 3.6×10−5 | 4.35×10−16 | 0.842 | ||
| Amplifying (RI<1) | Inhibitory | Inhibitory | Non-significant | Non-significant | Non-significant | Inhibitory | Inhibitory | Non-significant | ||
| MMR+Hib/MenC+PCV | 3 | 0.67 | 1.48 | 0.76 | 12.98 | 0.07 | 0.86 | 1.08 | 1.43 | 0.5 |
| (0.55 to 0.80) | (1.20 to 1.82) | (0.26 to 2.22) | (0.00-inf) | (0.01 to 0.41) | (0.36 to 2.06) | (0.87 to 1.34) | (1.26 to 1.63) | (0.20 to 1.28) | ||
| 2.01×10−5 | 2.15×10−4 | 0.614 | 1 | 0.003 | 0.741 | 0.472 | 8.64×10−8 | 0.15 | ||
| Inhibitory | Amplifying | Non-significant | Non-significant | Inhibitory | Non-significant | Non-significant | Amplifying | Non-significant | ||
| MMR+PCV | 2 | 1.91 | 0.76 | 0.9 | 0.21 | 1.56 | 2.04 | 1.06 | 0.79 | 1.22 |
| (1.83 to 1.99) | (0.72 to 0.80) | (0.72 to 1.13) | (0.08 to 0.54) | (0.85 to 2.88) | (1.67 to 2.49) | (1.01 to 1.11) | (0.77 to 0.81) | (0.94 to 1.58) | ||
| < 2×10−16 | < 2×10−16 | 0.381 | 0.013 | 0.152 | 3.13×10−12 | 0.018 | < 2×10−16 | 0.144 | ||
| Amplifying | Inhibitory | Non-significant | Inhibitory | Non-significant | Amplifying | Amplifying | Inhibitory | Non-significant | ||
| (B) RIR and interaction effects of the adverse events for all never recommended coadministrations studied | ||||||||||
| DTaP/IPV or dTaP/IPV+Hib/MenC | 2 | 0.52 | 0.73 | 0.76 | – | 0.84 | 1.01 | 0.98 | 0.63 | 1.00 |
| (0.35 to 0.77) | (0.45 to 1.18) | (0.24 to 2.42) | – | (0.20 to 3.55) | (0.32 to 3.24) | (0.52 to 1.12) | (0.50 to 0.80) | (0.24 to 4.11) | ||
| 0.001 | 0.198 | 0.645 | – | 0.812 | 0.982 | 0.161 | 0.0001 | 0.997 | ||
| Inhibitory | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Inhibitory | Non-significant | ||
| DTaP/IPV or dTaP/IPV+ MMR + Hib/MenC | 3 | 0.80 | 0.65 | 1.11 | – | 0.64 | 0.70 | 1.04 | 1.08 | 0.59 |
| (0.37 to 1.75) | (0.25 to 1.72) | (0.10 to 12.89) | – | (0.04 to 11.67) | (0.06 to 8.38) | (0.48 to 2.27) | (0.66 to 1.76) | (0.03 to 10.24) | ||
| 0.578 | 0.388 | 0.934 | – | 0.766 | 0.778 | 0.925 | 0.760 | 0.720 | ||
| Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | ||
| DTaP/IPV or dTaP/IPV+PCV | 2 | 0.40 | 0.90 | 1.12 | 2.78×10−8 | 1.11×10−4 | 0.58 | 0.77 | 0.79 | 0.85 |
| (0.30 to 0.54) | (0.76 to 1.06) | (0.41 to 3.03) | (0.00-inf) | (5.11×10−135 to 20.40×10+126) | (0.18 to 1.86) | (0.62 to 0.96) | (0.71 to 0.87) | (0.27 to 2.72) | ||
| 3.66×10-10 | 0.192 | 0.831 | 0.995 | 0.953 | 0.362 | 0.019 | 1.11×10-5 | 0.789 | ||
| Inhibitory | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Inhibitory | Inhibitory | Non-significant | ||
| DTaP/IPV/Hib + MenB+MenC + RV | 4 | 2.18 | 1.00 | 4.61×10+5 | – | – | 1.56×10+4 | 0.65 | 0.57 | 4.24×10+4 |
| (0.42 to 11.21) | (0.33 to 3.07) | (4.06×10−260 to 50.23×10+270) | – | – | (0.00-inf) | (0.24 to 1.75) | (0.30 to 1.05) | (0.00-inf) | ||
| 0.351 | 0.998 | 0.967 | – | – | 0.991 | 0.390 | 0.073 | 0.990 | ||
| Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | ||
| DTaP/IPV/Hib+MMR | 2 | 1.18 | 0.59 | 1.26 | 2.10×10−7 | 3.56 | 1.48 | 0.84 | 0.63 | 1.78 |
| (0.92 to 1.52) | (0.45 to 0.78) | (0.62 to 0.2.56) | (0.00-inf) | (1.21 to 10.50) | (0.55 to 4.00) | (0.64 to 1.09) | (0.55 to 0.73) | (0.72–4.38) | ||
| 0.186 | 0.0002 | 0.523 | 0.993 | 0.021 | 0.442 | 0.187 | 1.71×10−9 | 0.209 | ||
| Non-significant | Inhibitory | Non-significant | Non-significant | Amplifying | Non-significant | Non-significant | Inhibitory | Non-significant | ||
| MMR+MenB + MenC+ PCV | 4 | 5585 | 2388 | – | – | – | 8.73×10−11 | 3029 | – | – |
| (5.71×10−112 to 50.47×10+118) | (9.26×10−158 to 60.16×10+163) | – | – | – | (0.00 to inf) | (4.53×10−105 to 20.02×10+111) | – | – | ||
| 0.949 | 0.967 | – | – | – | 0.992 | 0.950 | – | – | ||
| Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | ||
| MMR+MenC | 2 | 1.58 | 0.65 | 0.55 | 4.19×10−8 | 2.33 | 0.73 | 0.97 | 0.71 | 0.98 |
| (1.37 to 1.82) | (0.55 to 0.76) | (0.23 to 1.34) | (0.00 to inf) | (0.81 to 6.66) | (0.27 to 1.98) | (0.85 to 1.11) | (0.65 to 0.78) | (0.31–3.11) | ||
| 1.57×10−10 | 1.18×10−7 | 0.188 | 0.994 | 0.116 | 0.538 | 0.664 | 1.09×10−13 | 0.974 | ||
| Amplifying | Inhibitory | non-significant | non-significant | non-significant | non-significant | non-significant | Inhibitory | non-significant | ||
| MMR+MenC + PCV | 3 | 0.37 | 1.68 | 11.83 | 1.85 | 3.89×10−4 | 0.24 | 1.27 | 1.07 | 0.64 |
| (0.27 to 0.51) | (1.07 to 2.64) | (1.28 to 109.01) | (0.00 to inf) | (5.81×10−99 to 20.6×10+91) | (0.02 to–2.37) | (0.83 to 1.94) | (0.85 to 1.34) | (0.06–7.46) | ||
| 1.81×10−9 | 0.023 | 0.029 | 1 | 0.944 | 0.221 | 0.27 | 0.554 | 0.722 | ||
| Inhibitory | Amplifying | Amplifying | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | ||
| MMR+Td/IPV | 2 | 1.11 | 1.00 | 1.26 | – | 0.71 | 0.77 | 1.05 | 0.88 | 1.82 |
| (0.78 to 1.57) | (0.70 to 1.43) | (0.79 to 2.01) | – | (0.31 to–1.63) | (0.22 to 2.73) | (0.79 to 1.41) | (0.74 to 1.04) | (0.77-.4.27) | ||
| 0.563 | 0.982 | 0.336 | – | 0.423 | 0.69 | 0.723 | 0.128 | 0.171 | ||
| Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | ||
| Td/IPV+HPV | 2 | 1.29 | 0.65 | 0.84 | – | 1.14 | 4.5 | 0.37 | 1.14 | 5.07×10−5 |
| (0.17 to 9.51) | (0.09 to 4.73) | (0.37 to 1.89) | – | (0.42 to 3.08) | (0.56 to–36.15) | (0.05 to 2.68) | (0.59 to 2.22) | (2.64×10−201-90.72×10+191) | ||
| 0.805 | 0.673 | 0.677 | – | 0.801 | 0.157 | 0.328 | 0.694 | 0.966 | ||
| Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | Non-significant | ||