Table 2

Three-year study period and lifetime projections of YLD within core sample, disaggregated by the severity of HRQoL impairment at T0, and presented for the total cohort, and stratified by gender and HIV status

Disability over the 3- year follow-up periodProjected lifetime disability (including 3-year post-treatment)Disability weights
NMean YLDTotal YLDBurdenNMean YLDTotal YLDBurdenDuring 3 yearsAfter 3 years
All participants in core sample (n=299)*Least severe 20%940.0000.0000%940.0000.0000%0.0000.000
300.0120.3711%290.0120.3600%0.0040.000
550.0412.2388%570.0422.4191%0.0140.000
600.1116.67224%600.1549.2535%0.0370.000
Most severe 20%600.31518.89067%593.062180.62994%0.1050.083
All 3-year participants2990.09428.171100%2990.644192.662100%0.0310.016
Men (n=198)Least severe 20%700.0000.0000%380.0000.0000%0.0000.000
110.0090.1021%100.0090.0920%0.0030.000
380.0381.4278%380.0381.4382%0.0130.000
410.1074.39025%400.1345.3656%0.0360.000
Most severe 20%380.30711.66166%402.09683.84592%0.1020.060
All men1980.08917.580100%1980.45890.739100%0.0300.012
Women (n=101)Least severe 20%240.0000.0000%240.0000.0000%0.0000.000
190.0150.2863%190.0150.2860%0.0050.000
180.0480.8678%180.0500.9011%0.0160.000
210.1392.91227%200.2244.4834%0.0460.001
Most severe 20%190.3436.52562%204.81396.25394%0.1140.125
All women1010.10510.591100%1011.009101.923100%0.0350.025
HIV-positive participants (n=179)Least severe 20%570.0000.0000%570.0000.0000%0.0000.000
190.0130.2462%190.0130.2460%0.0040.000
350.0391.37310%330.0381.2682%0.0130.000
320.0902.87622%340.1083.6635%0.0300.000
Most severe 20%360.2438.75966%362.06974.47193%0.0810.052
All HIV positive1790.07413.254100%1790.44579.649100%0.0250.010
HIV-negative participants (n=119)Least severe 20%370.0000.0000%370.0000.0000%3.3330.000
110.0110.1251%100.0110.1150%8.0000.000
230.0481.1138%240.0551.3171%8.0000.000
240.1613.85226%240.2696.4516%8.0000.002
Most severe 20%240.4009.59365%244.321103.71493%39.6670.122
All HIV negative1190.12314.683100%1190.938111.597100%0.0410.025
  • Shaded cells show average DWs for each subgroup, appropriate for YLD calculations in an economic evaluation. They are calculated as the mean 3-yearYLD divided by three. For HIV status within gender, see online supplemental appendix table F3.

  • *Note least severe groupings larger due to number of participants measuring no impairment at T0. Further note, grouping by HIV status does not include one participant who declined testing.

  • HRQoL, health-related quality of life; YLD, years of life lost due to disability.