Estimated incremental cost-effectiveness of a representative HCD-informed intervention
| Per client cost | Low HCD up-front cost (US$178 000) | Mid HCD up-front cost (US$356 000) | High HCD up-front cost (US$534 000) | |||||||||
| US$0.10 | US$1 | US$20 | US$100 | US$0.10 | US$1 | US$20 | US$100 | US$0.10 | US$1 | US$20 | US$100 | |
| Incremental cost-effectiveness (2000 clients reached, 0.05 DALYs averted per client) | ||||||||||||
| Incremental cost per DALY averted | US$1782 | US$1800 | US$2180 | US$3780 | US$3562 | US$3580 | US$3960 | US$5560 | US$5342 | US$5360 | US$5740 | US$7340 |
| Number of clients that must be reached to achieve cost-effectiveness (0.05 DALYs averted per client) | ||||||||||||
| US$1000/DALY threshold | 3570 | 3630 | 5930 | * | 7130 | 7270 | 11 900 | * | 10 700 | 10 900 | 17 800 | * |
| US$500/DALY threshold | 7150 | 7420 | 35 600 | * | 14 300 | 14 800 | 71 200 | * | 21 400 | 22 300 | 106 800 | * |
| Number of DALYs that must be averted per client reached to achieve cost-effectiveness (2000 clients reached) | ||||||||||||
| US$1000/DALY threshold | 0.089 | 0.09 | 0.109 | 0.19 | 0.178 | 0.179 | 0.198 | 0.28 | 0.267 | 0.268 | 0.287 | 0.37 |
| US$500/DALY threshold | 0.178 | 0.18 | 0.218 | 0.38 | 0.356 | 0.358 | 0.396 | 0.56 | 0.534 | 0.536 | 0.574 | 0.74 |
*Cannot achieve cost-effectiveness because US$100 per client (at 0.05 DALYs averted per client) would exceed the threshold.
DALY, disability-adjusted life year; HCD, human-centred design.