Table 1

Summary of findings from research studies of caffeine citrate in preterm infants

Infant populationBenefitsSource of evidence
Birth weight 500–1250 g
  1. Reduced risk of neurodisability at 18–21 months

  2. Improved cognitive development at 18–21 months

High-income countries
Infants ≤34 weeks gestation
  1. Reduction in apnoea (equivocal)

  2. Reduction in bronchopulmonary dysplasia (chronic lung disease)

  3. Reduction in severe retinopathy of prematurity

High-income and low-income and middle-income countries