Publication | Location | Sample size | Population studied | Prevalence of mental disorders |
Cochrane and Knapper28 | Wales | n=176 | Individuals commencing PrEP across a network of sexual and reproductive health clinics | Electronic health record documentation of ‘mental health issues,’ 24% |
Doblecki-Lewis et al64 | USA | n=554 | Participants in a multicity PrEP demonstration project | Positive screen for depression (PHQ-2), 23.8% |
Haberer et al65 | Kenya and Uganda | n=985 | HIV-negative partners in serodiscordant relationships as part of a PrEP demonstration project | Positive screen for depression (Hopkins Checklist>1.75), 10% |
Krakower et al9 | USA | n=663 | Individuals prescribed PrEP at an urban community health centre | Electronic health record documentation of anxiety disorders, 37.3%; depressive disorders, 36.2%; attention-deficit/hyperactivity disorder, 16.0%; post-traumatic stress disorder, 5%; and bipolar disorder or schizophrenia, 3.6% |
Rusie et al66 | USA | n=3451 | Individuals starting PrEP in an urban network of community health centres | One or more mental health conditions, 20.6%; >2 mental health conditions, 5.2% |
Scott et al67 | USA | n=348 | Individuals initiating PrEP across primary care clinics in an urban municipal health network | Electronic medical record documentation of anxiety disorders, 9%; depressive disorders, 22%; post-traumatic stress disorder, 7%; and bipolar disorder or schizophrenia, 10% |
Serota et al68 | USA | n=131 | A longitudinal cohort of young, black men who have sex with men in an urban area | Moderate to severe symptoms of anxiety (GAD-7), 22%; moderate to severe symptoms of depression (PHQ-8), 17% |
Spinelli et al69 | USA | n=364 | Individuals prescribed PrEP across primary care clinics in an urban municipal health system | Electronic medical record documentation of anxiety or depressive disorder, 31%; and bipolar disorder or schizophrenia, 9% |
van Epps et al70 | USA | n=1086 | Individuals initiating PrEP in the Veteran Health Affairs health system | Electronic medical record documentation of depression, 53.4% |
Zucker et al71 | USA | n=696 | Individuals assessed for HIV prevention services in an urban hospital network | Mild to severe symptoms of depression (PHQ-9), 17.6% |
GAD-7, 7-item Generalised Anxiety Disorder scale; PHQ-2, 2-item Patient Health Questionnaire; PHQ-8, 8-item Patient Health Questionnaire; PHQ-9, 9-item Patient Health Questionnaire; PrEP, pre-exposure prophylaxis.