Table 1

Prevalence of mental disorders and poor mental health among people initiating PrEP

PublicationLocationSample sizePopulation studiedPrevalence of mental disorders
Cochrane and Knapper28Walesn=176Individuals commencing PrEP across a network of sexual and reproductive health clinicsElectronic health record documentation of ‘mental health issues,’ 24%
Doblecki-Lewis et al64USAn=554Participants in a multicity PrEP demonstration projectPositive screen for depression (PHQ-2), 23.8%
Haberer et al65Kenya and Ugandan=985HIV-negative partners in serodiscordant relationships as part of a PrEP demonstration projectPositive screen for depression (Hopkins Checklist>1.75), 10%
Krakower et al9USAn=663Individuals prescribed PrEP at an urban community health centreElectronic health record documentation of anxiety disorders, 37.3%; depressive disorders, 36.2%; attention-deficit/hyperactivity disorder, 16.0%; post-traumatic stress disorder, 5%; and bipolar disorder or schizophrenia, 3.6%
Rusie et al66USAn=3451Individuals starting PrEP in an urban network of community health centresOne or more mental health conditions, 20.6%; >2 mental health conditions, 5.2%
Scott et al67USAn=348Individuals initiating PrEP across primary care clinics in an urban municipal health networkElectronic medical record documentation of anxiety disorders, 9%; depressive disorders, 22%; post-traumatic stress disorder, 7%; and bipolar disorder or schizophrenia, 10%
Serota et al68USAn=131A longitudinal cohort of young, black men who have sex with men in an urban areaModerate to severe symptoms of anxiety (GAD-7), 22%; moderate to severe symptoms of depression (PHQ-8), 17%
Spinelli et al69USAn=364Individuals prescribed PrEP across primary care clinics in an urban municipal health systemElectronic medical record documentation of anxiety or depressive disorder, 31%; and bipolar disorder or schizophrenia, 9%
van Epps et al70USAn=1086Individuals initiating PrEP in the Veteran Health Affairs health systemElectronic medical record documentation of depression, 53.4%
Zucker et al71USAn=696Individuals assessed for HIV prevention services in an urban hospital networkMild to severe symptoms of depression (PHQ-9), 17.6%
  • GAD-7, 7-item Generalised Anxiety Disorder scale; PHQ-2, 2-item Patient Health Questionnaire; PHQ-8, 8-item Patient Health Questionnaire; PHQ-9, 9-item Patient Health Questionnaire; PrEP, pre-exposure prophylaxis.