Cost and YLL summaries (95% credible interval from probabilistic sensitivity analyses) based on POM contacts received versus control arm
| India health system perspective | Mozambique health system perspective | Pakistan health system perspective | Pakistan societal perspective* | ||||||||||||||
| YLL | Incremental YLL | Incremental cost | ICER | YLL | YLL intervention–control | Incremental cost | ICER | YLL | YLL intervention–control | Incremental cost | ICER | YLL | Incremental YLL | Cost | Incremental cost | ICER | |
| Control | 3.36 (2.97, 3.78) | – | – | 3.25 (2.65, 3.94) | – | – | 7.63 (7.16, 8.11) | – | – | 7.63 (7.16, 8.11) | 132.33 (116.79, 145.04). | ||||||
| Intervention | – | – | – | – | – | – | – | – | – | – | – | – | |||||
| Overall | 3.74 (2.68, 5.60) | 0.38 (−0.82, 2.28) | 13.0 (2.29, 23.6) | Intervention is dominated.† | 3.67 (2.42, 5.65) | 0.41 (−1.00, 2.43) | 15.7 (1.40, 40.05) | Intervention is dominated.† | 7.29 (5.23, 9.26) | −0.33 (−2.39, 1.60) | 11.8 (3.70, 23.41) | 12.94 (−188, 144) | 7.29 (5.23, 9.26) | −0.34 (−2.38, 1.62) | 155.75 (138.41, 174.89) | 23.04 (0.41, 48.31) | 67.80 (−316, 330) |
| 0 POM-guided contact | 3.41 (2.52, 4.43) | 0.05 (−0.94, 1.10) | 1.01 (0.49, 1.73) | Intervention is dominated.† | 3.13 (2.69, 3.62) | −0.12 (−0.93, 0.64) | 1.35 (0.71, 2.12) | 11.25 (−45.6, 45.7) | 7.65 (7.04, 8.30) | 0.03 (−0.76, 0.82) | 3.91 (2.77, 5.25) | Intervention is dominated.† | 7.65 (7.04, 8.30) | 0.03 (−0.77, 0.83) | 143.39 (133.67, 152.53) | 11.03 (0.00, 28.24) | Intervention is dominated.† |
| 1–3 POM-guided contacts | 4.53 (3.02, 6.42) | 1.16 (−0.43, 3.07) | 3.51 (1.84, 5.77) | Intervention is dominated.† | 5.85 (4.69, 7.12) | 2.60 (1.28, 4.03) | 9.66 (4.80, 16.18) | Intervention is dominated.† | 9.42 (8.46, 10.43) | 1.80 (0.72, 2.94) | 9.56 (6.21, 13.59) | Intervention is dominated.† | 9.42 (8.46, 10.43) | 1.80 (0.72, 2.92) | 150.87 (131.70,165.68) | 18.51 (0.00, 40.21) | Intervention is dominated.† |
| 4–7 POM-guided contacts | 5.23 (4.03, 6.68) | 1.87 (0.58 3.34) | 8.06 (5.57, 11.02) | Intervention is dominated.† | 4.34 (3.60, 5.16) | 1.09 (0.08, 2.09) | 22.10 (14.97, 30.52) | Intervention is dominated.† | 6.65 (6.21, 7.11) | −0.98 (−1.63, −0.31) | 17.48 (12.72, 22.96) | 17.84 (9.68, 51.0) | 6.65 (6.21, 7.11) | −0.98 (−1.63, −0.30) | 167.89 (156.56, 176.35) | 35.54 (18.73, 53.70) | 36.26 (15.10, 114) |
| ≥8 POM-guided contacts | 2.94 (2.46, 3.45) | −0.43 (−1.07, 0.22) | 18.60 (11.30, 28.2) | 43.28 (−359, 426) | 2.44 (1.89, 3.08) | −0.81 (−1.70, 0.07) | 39.45 (26.15, 55.32) | 48.70 (−155, 323) | 4.80 (4.15, 5.48) | −2.83 (−3.64, −1.99) | 25.78 (21.49, 30.32) | 9.11 (6.64, 13.20) | 4.80 (4.15, 5.48) | −2.83 (−3.64, −1.99) | 177.22 (169.14, 183.17) | 44.87 (29.61, 61.28) | 15.86 (9.65, 25.7) |
All intervals are 95% credible intervals based on the probabilistic sensitivity analysis.
All data are per pregnancy, comparisons are to the control arm and all costs are in US$.
*Includes health system utilisation costs from care seeking reported by focus group.
†Indicates that the intervention has no benefit in years of life lost.
ICER, incremental cost-effectiveness ratio; POM, PIERS (Pre-eclampsia Integrated Estimate of RiSk) On the Move; YLL, years of life lost.