Table 1

Key tafenoquine trials

S. noTrial/studyPlace/yearTotal no. of participantsRecurrence free rate of CQ+PQRecurrence free rate of CQ+TQ (single dose)
1.DETECTIVE Part 1
NCT01376167
Phase IIb/III trial25
Brazil
Peru
India
Thailand
2011–2013
329 total77%
(95% CI 63% to 87%)
50 mg: 58% (95% CI 43% to 70%)
100 mg: 54% (95% CI 40% to 66%)
300 mg: 89% (95% CI 77% to 95%)
600 mg: 92% (95% CI 80% to 97%)
2.DETECTIVE Part 2
NCT01376167
Phase III Trial26
Brazil
Peru
Colombia
Thailand
Philippines
Ethiopia
2015–2016
522 total70% (95% CI 60% to 77%)62% (95% CI 55% to 69%)
3.GATHER
NCT02216123
Phase III Trial22
Brazil
Colombia
Ethiopia
Peru
Thailand
Vietnam
2014–2016
251 total75% (95% CI 64% to 83%)73% (95% CI 65% to 79%)
  • CQ, chloroquine; PQ, primaquine; TQ, tafenoquine.