Table 2

Difference between measured number of RCTs, and number predicted based on global disease burden (negative numbers=fewer RCTs were published than predicted)

Disease category	Total (1990– 2017)	1990– 1993	1994– 1997	1998– 2001	2002– 2005	2006– 2009	2010– 2013	2014– 2017
Cardiovascular diseases	+34 000	+2400	+3000	+3600	+4400	+5100	+6700	+8300
Chronic respiratory diseases	+4200	+370	+500	+670	+720	+710	+620	+630
Diabetes and kidney diseases	+10 000	+490	+710	+800	+1200	+1600	+2400	+3400
Digestive diseases	+7700	+590	+850	+920	+1100	+1100	+1400	+1700
Enteric infections	−9700	−950	−1200	−1200	−1400	−1500	−1700	−1800
HIV/AIDS and sexually transmitted infections	−1100	−120	−180	−190	−400	−280	−51	+100
Maternal and neonatal disorders	+6400	+120	+410	+440	+530	+670	+1500	+2700
Mental disorders	+38 000	+1100	+1900	+2600	+4100	+6100	+9200	+13 000
Musculoskeletal disorders	+5900	+50	+130	+360	+780	+1000	+1600	+2000
Neglected tropical diseases and malaria	−5400	−470	−570	−650	−790	−880	−990	−1100
Neoplasms	+14 000	+980	+1300	+1200	+1700	+2200	+3000	+4000
Neurological disorders	+25 000	+1100	+1700	+2100	+2800	+3800	+5600	+7800
Nutritional deficiencies	−3300	−380	−450	−460	−410	−520	−560	−530
Other infectious diseases	−2500	−390	−400	−340	−350	−260	−350	−410
Other non-communicable diseases	+24 000	+890	+1400	+1800	+2800	+3900	+6100	+7400
Respiratory infections and tuberculosis	−7000	−830	−980	−970	−1100	−1200	−1100	−1000
Self-harm and interpersonal violence	−6800	−620	−840	−890	−920	−1,000	−1,200	−1,300
Sense organ diseases	+6500	+470	+630	+800	+780	+1000	+1300	+1500
Skin and subcutaneous diseases	+9300	+660	+780	+980	+1200	+1500	+1900	+2300
Substance use disorders	+9800	+370	+750	+870	+1200	+1700	+2200	+2700
Transport injuries	−8000	−670	−840	−940	−1100	−1200	−1500	−1700
Unintentional injuries	+6300	+91	+200	+310	+620	+840	+1600	+2600

RCTs, randomised controlled trials.