Table 2

Occurrence and duration of side effects

StudySide-effect
NauseaHeavy bleeding*VomitingPain/crampsFever/chills
Mean # of days (SD)% who reportedMean # of days (SD)% who reportedMean # of days (SD)% who reportedMean # of days (SD)% who reportedMean # of days (SD)% who reported
HCHCHCHCHCHCHCHCHCHC
Akin et al 2004242.0 (2.8)1.8 (2.0)NRNR2.1 (2.3)1.7 (2.5)NRNR0.8 (2.0)0.4 (1.0)NRNR2.9 (3.1)2.6 (3.4)NRNR1.0 (2.4)0.4 (0.07)NRNR
Alam et al 201325NRNR33.849.5NRNR69.865.1NRNR23.725.7NRNRNRNRNRNRNRNR
Alam et al 201826NRNR70.371.1NRNR0.020NRNR29.423.1NRNRNRNRNRNR45.743.8
Bracken et al 2006271.1 (1.4)1.2 (1.4)62.466.71.9 (1.7)2.0 (2.0)NRNR0.7 (1.2)0.7 (1.1)33.733.30.6 (1.2)0.5 (1.2)34.825.90.3 (0.8)0.3 (0.7)23.3.22.2
Iygenar et al 201630NRNRNRNRNRNR7.23.6NRNRNRNRNRNR5.94.2NRNR7.66.3
Li et al 201721NRNR17.316.8NRNRNRNRNRNR3.84.3NRNR48.550.8NRNRNRNR
Ngoc et al 2004321.50.8*NRNR2.52.4NRNR0.60.2*NRNR1.71.4*NRNR0.40*NRNR
Okonofua et al 2014360.4 (0.9)0.6 (0.9)24.036.73.3 (2.5)3.1 (1.7)86.490.00.4 (0.7)0.2 (0.7)29.213.31.4 (1.5)1.8 (1.5)61.066.70.3 (1.0)0.3 (0.8)12.313.3
Raghavan et al 2012330.4 (0.9)0.6 (0.9)2436.73.3 (2.5)3.1 (1.7)86.4900.4 (0.7)0.2 (0.7)29.213.31.4 (1.5)1.8 (1.5)6166.70.3 (1.0)0.3 (0.8)12.313.3
Shresthra et al 201422NRNR5.416.3NRNRNRNRNRNR5.46.52.1 (1.7)2.01 (1.8)NRNRNRNRNRNR
Shuchita et al 2008342.4 (2.0)1.8 (0.8)52.557.13.5 (2.6)3.3 (1.9)87.180.91.7 (1.1)1.2 (0.4)44.847.63.8 (3.2)2.0 (3.6)69.266.62.4 (2.0)2.3 (2.3)30.719
Song et al 201823NRNR42.839.6NRNRNRNRNRNR7.47.2NANA74.971.2NRNRNRNR

  • Provansal et al 2009,16 Karki et al 2009,31 Hajri et al 2004,29 Elul et al35, Dagousset et al17 2004, Bracken et al 201028 did not report any data on side effects.

  • *P<0.05.

  • C, clinic; H, home; NA, not available; NR, not reported.