Facilities reporting use of medicines to treat paediatric cancers
| Medicine | Income group (no of facilities) | Proportion reporting use Median % (IQR %) |
| SIOP core | ||
| l-asparaginase (i), bleomycin (i), carboplatin (i), cisplatin (i), cyclophosphamide (t), cyclophosphamide (i), cytarabine (i), dacarbazine (i), dactinomycin (i), daunorubicin (i), doxorubicin (i), etoposide (c), etoposide (i), hydroxycarbamide (t/c), ifosfamide (i), mercaptopurine (t), methotrexate (t), methotrexate (i), thioguanine (t), vinblastine (i), vincristine (i) | HIC2 (14) | 100 (93–100) |
| HIC1 (5) | 100 (100–100) | |
| UMC (15) | 100 (87–100) | |
| LMC (16) | 81 (69–81) | |
| LIC (8) | 88 (75–88) | |
| Kruskal-Wallis test | P value <0.0001 | |
| SIOP Ancillary | ||
| 13-cis retinoic acid (t/c), all-trans retinoic acid ATRA (c), busulphan (t), imatinib (t), irinotecan (i), melphalan (t), topotecan (i), vinorelbine (i) | HIC2 (14) | 96 (75–100) |
| HIC1 (5) | 80 (55–100) | |
| UMC (15) | 83 (70–88) | |
| LMC (16) | 31 (31–41) | |
| LIC (8) | 19 (13–31) | |
| Kruskal-Wallis test | P value=0.0002 | |
| WHO EMLc | ||
| Calcium folinate (leucovorin) (i), calcium folinate (leucovorin) (t), filgrastim (i), mesna (t), mesna (i) | HIC2 (14) | 93 (86–93) |
| HIC1 (5) | 100 (80–100) | |
| UMC (15) | 100 (87–100) | |
| LMC (16) | 63 (31–69) | |
| LIC (8) | 50 (50–63) | |
| Kruskal-Wallis test | P value=0.068 | |
(c) capsule; (i) injection; (t) tablet.
HIC2: Australia, Belgium, Canada, Finland, France, Italy, Japan, New Zealand, Qatar, Spain, UK (two facilities), USA (2).
HIC1: Latvia, Malta, Saudi Arabia, Chile (2).
UMC: Angola, Brazil (2), China, Colombia, Dominican Republic, Georgia, Iran, Iraq, Jordan, Malaysia, Panama, Russian Federation, South Africa, Thailand.
LMC: Armenia, Cameroon (2), Ghana, Guatemala, India, Indonesia, Kenya, Kyrgyzstan, Morocco, Myanmar, Nigeria (2) Sudan, Vietnam (2).
LIC: Ethiopia (2), Haiti, Malawi, Nepal, Rwanda, Senegal, Zimbabwe.
EMLc, Essential Medicines for Children; HIC, high-income country; LIC, low-income country; LMC, lower-middle-income country; SIOP, International Society of Paediatric Oncology; UMC, upper-middle-income country.