Table 1

Participating study site settings and corresponding ethical boards that approved BFF-Dx

InstituteInstituto Nacional de Infectologia Evandro Chagas (INI), FIOCRUZ, Rio de JaneiroCenter of Medical Research Lambaréné (CERMEL)Malawi Epidemiology and Intervention Research Unit (MEIRU)
Enrolment siteUPA Rocha Miranda, UPA Manguinhos and Family Health Clinics Armando PalharesClinical trials unit, CERMELMEIRU, Chilumba campus
Enrolment settingPrimary healthcare facility in an urban area (favela)Hospital in a semirural settingPrimary healthcare facility in a rural setting
Enrolment periodOctober 2018 to July 2019May 2019 to November 2019April 2017 to
April 2018
Main causes of fever (expected)Circulation of arboviruses, including dengue, Zika and chikungunya virusesEndemic Plasmodium falciparum, dengue virus and chikungunya virusEndemic Plasmodium falciparum and possibly chikungunya virus
  • BFF-Dx, Biomarker for Fever-Diagnostic.