Table 5

Univariable and multivariable meta-regression models for proportion measures of herpes simplex virus type 1 virus isolation in clinically diagnosed genital herpes in Europe

Outcome measureSampleUnivariable analysisMultivariable analysis
Model 1*Model 2†
Total nTotal NRR (95% CI)P valueLR test p valueAdjusted R2 (%)ARR (95% CI)P valueARR (95% CI)P value
Age group (years)
 <2031571.000.3940.00
 20–3066430.71 (0.29 to 1.71)0.447
 30–4021020.78 (0.25 to 2.44)0.675
 Mixed15140 1790.58 (0.28 to 1.21)0.147
Sex
 Women6249331.000.00111.271.001.00
 Men5635780.63 (0.50 to 0.80)<0.0010.62 (0.50 to 0.76)<0.0010.61 (0.49 to 0.75)<0.001
 Mixed4432 5700.63 (0.65 to 1.02)0.0740.81 (0.65 to 1.00)0.0610.81 (0.66 to 1.01)0.067
Genital herpes episode status
 First episode genital herpes1313661.00<0.00112.191.001.00
 Recurrent genital herpes118930.27 (0.17 to 0.47)<0.0010.29 (0.49 to 0.93)0.0160.27 (0.17 to 0.44)<0.001
 Unspecified status13838 8220.68 (0.49 to 0.95)0.0260.67 (0.49 to 0.92)0.0160.66 (0.48 to 0.89)0.008
European subregion/country
 Northern Europe13138 8431.000.3970.61
 Eastern Europe21001.44 (0.59 to 3.46)0.417
 Southern Europe82860.79 (0.44 to 1.40)0.424
 Western Europe54620.63 (0.34 to 1.13)0.119
 Israel46051.38 (0.74 to 2.60)0.304
 Mixed subregions127850.89 (0.60 to 1.34)0.600
Sample sizec‡
 <1005639051.000.5910.00
 ≥10010637 1761.06 (0.85 to 1.32)0.591
Year of publication range
 <20007450721.000.0213.951.00
 2000–20105387270.86 (0.68 to 1.08)0.1930.94 (0.76 to 1.16)0.555
 >20103527 2821.26 (0.98 to 1.63)0.0701.26 (1.00 to 1.58)0.049
Year of publication16241 0811.01 (1.00 to 1.02)0.0430.0432.571.01 (1.00 to 1.02)0.014
  • *Variance explained by the final multivariable model 1 (adjusted R2 )=26.10%.

  • †Variance explained by the final multivariable model 2 (adjusted R2 )=28.38%.

  • ‡Sample size denotes the sample size of the study population found in the original publication.

  • ARR, adjusted risk ratio; HSV-1, herpes simplex virus type 1; RR, risk ratio.