Effect estimates with and without adjustment for baseline values of outcome variables1
Model | Not adjusted | Adjusted for baseline 1 (before follow-up began)* | Adjusted for baseline 2 (before training began)* | ||||||
OR | 95% CL | P value | OR | 95% CL | P value | OR | 95% CL | P value | |
Participants with asthma | |||||||||
†Asthma score‡ | 1.32 | 1.08 to 1.61 | 0.006 | 1.15 | 0.94 to 1.41 | 0.173 | 1.24 | 1.03 to 1.50 | 0.022 |
Asthma score: start or change treatment§ | 1.30 | 1.06 to 1.58 | 0.012 | 1.21 | 1.01 to 1.45 | 0.041 | 1.24 | 1.04 to 1.47 | 0.014 |
Asthma score: spirometry§ | 1.37 | 1.07 to 1.75 | 0.012 | 1.14 | 0.85 to 1.51 | 0.384 | 1.34 | 1.04 to 1.72 | 0.023 |
Participants with COPD | |||||||||
†COPD score‡ | 1.21 | 0.94 to 1.55 | 0.142 | 1.06 | 0.81 to 1.39 | 0.664 | 1.15 | 0.89 to 1.47 | 0.284 |
COPD score: start or change treatment§ | 1.06 | 0.79 to 1.41 | 0.699 | 1.20 | 0.88 to 1.65 | 0.253 | 1.11 | 0.82 to 1.51 | 0.493 |
COPD score: spirometry§ | 1.31 | 1.00 to 1.73 | 0.053 | 1.04 | 0.73 to 1.49 | 0.812 | 1.24 | 0.94 to 1.65 | 0.130 |
Participants with asthma or COPD | |||||||||
Cardiovascular disease newly diagnosed§ | 1.06 | 0.80 to 1.40 | 0.705 | 1.02 | 0.78 to 1.33 | 0.905 | 1.05 | 0.80 to 1.38 | 0.745 |
Cardiovascular risk assessed§ | 0.95 | 0.75 to 1.21 | 0.698 | 0.93 | 0.80 to 1.9 | 0.380 | 0.93 | 0.78 to 1.10 | 0.404 |
Diabetes newly diagnosed§ | 1.47 | 0.99 to 2.20 | 0.057 | 1.45 | 1.02 to 2.07 | 0.039 | 1.42 | 0.94 to 2.12 | 0.092 |
Nicotine or buproprion or nortriptyline prescribed§ | 1.14 | 0.83 to 1.55 | 0.419 | 1.14 | 0.81 to 1.59 | 0.455 | 0.13 | 0.83 to 1.54 | 0.420 |
Depression newly diagnosed§ | 1.29 | 0.82 to 2.03 | 0.266 | 1.04 | 0.68 to 0.80 | 0.864 | 1.22 | 0.81 to 1.85 | 0.339 |
Antidepressant treatment started§ | 1.07 | 0.83 to 1.36 | 0.607 | 1.02 | 0.80 to 1.31 | 0.853 | 1.06 | 0.83 to 1.35 | 0.651 |
Clinic level diagnosis and hospital admission ratios¶ | Difference in means | 95% CL | P value | Difference in means | 95% CL | P value | Difference in means | 95% CL | P value |
†New asthma and COPD diagnoses** | −0.16 | −2.29 to 1.98 | 0.883 | −0.36 | −2.43 to 1.71 | 0.730 | 0.50 | −1.53 to 2.52 | 0.622 |
New asthma diagnoses** | −0.26 | −1.67 to 1.14 | 0.705 | −0.29 | −1.67 to 1.09 | 0.677 | −0.12 | −1.27 to 1.51 | 0.863 |
New COPD diagnoses** | −0.11 | −1.06 to 1.28 | 0.851 | −0.15 | −1.24 to 0.94 | 0.783 | 0.14 | −0.98 to 1.25 | 0.808 |
Hospital admissions for asthma or COPD** | −0.08 | −0.76 to 1.01 | 0.882 | 0.23 | −0.27 to 0.74 | 0.354 | −0.07 | −0.71 to 0.57 | 0.829 |
*Mean values of respective outcome variable in each clinic.
†Primary outcomes. Effects estimated with
‡Ordinal logistic regression models.
§Logistic regression models.
¶No of new diagnoses or hospital admissions: 1000 adults visiting clinic during the year.
**Linear regression models. All regression models adjusted for randomisation strata, and logistic and ordinal logistic regression models also adjusted for intra-cluster correlation of outcomes.
CL, confidence limits; COPD, chronic obstructive pulmonary disease.