A. Parameters governing the gametocyte dynamics | ||

Parameter | Distribution | Description |

α | Log-normal distribution , . Distribution truncated at 0.3 | Commitment rate of asexual parasites |

Normal distribution, , . Distribution truncated at (1, 3) | Mean time spent in each immature gametocyte stage (in days) | |

Normal distribution, , . Distribution truncated at (1.4,16) | Mean circulation time of mature gametocytes (in days) |

B. Pharmacodynamic parameters for AL against gametocytes | ||||

Value for AM (95% credible intervals in brackets) | Value for LMF | Fixed or Fitted | ||

0.18 | 0.13 | Fixed | Max. killing rate of stage 1 and 2 gametocytes (1/hour) | |

0.11 (0.09–0.12) | 0.04 | Fitted for AM, fixed for LMF | Max. killing rate of stage 3 and 4 gametocytes (1/hour) | |

0.08 (0.07–0.10) | 0 | Fitted for AM, fixed for LMF | Max. killing rate of stage 5 (mature) gametocytes (1/hour) | |

3.3 | 125 | Fitted previously for asexual parasites14 | Drug concentration (ng/ml) at which killing rate is half of its maximum |

AL, artemether-lumefantrine; AM, artemether; LMF, lumefantrine.