Table 1

Measures to modify AMU

Health/clinicalAgriculture and foodWater, sanitation and environment
  • Adherence to therapies Integration of new diagnostics/therapy strategies

  • Effective health messaging and information

  • Promotion of antibiotics

  • Public health messages

  • Voluntary/mandatory/market-based incentives

  • Appropriate access

  • Issue mainstreaming

  • Experience of treatment campaigns

  • Human microbiome, nutritional status, coinfection

  • Available antibiotics

  • Drug combinations vs monotherapies

  • Drug dosage

  • Frequency of dosage

  • Packaging design

  • Syndromic treatment

  • Prophylactic treatment

  • Universal health coverage

  • Deferred prescriptions

  • Distinctive labelling

  • Patient screening and isolation

  • Watchful waiting

  • Nudging prescription habits

  • Breeding and precision editing

  • Microbiome manipulation

  • Vaccines/disease eradication

  • Phage and Lysins

  • Immunomodulation

  • Novel antimicrobials

  • In feed enzymes

  • Prebiotics and probiotics

  • Phytochemicals (eg, essential oils)

  • Biosecurity/heard health planning

  • Husbandry Housing and animal welfare

  • Shift away from growth promoters

  • Training veterinary medics in importance of responsible antibiotic use

  • Improved biosecurity at farms

  • Rapid and cheap diagnostics

  • Restrictions on highly critical antibiotics

  • Peptides

  • Antibodies

  • Improve carcass and food handling

  • Reduce effluents from farms

  • Improved sanitation

  • Improved access to clean water

  • Primary, secondary and tertiary water treatment

  • Regulatory standards on discharges of antibiotics from production facilities including determination of differentiated maximum admissible levels of an antibiotic, ARB or ARG

  • Farm waste management membrane filtration, activated carbon bio filters, photo-driven technologies and ozonation, wetland-treatment

  • Infection prevention and control