Summary of effect sizes and meta-analyses
Outcome | Study type | Number of effect sizes | RR1 | 95% CI | P value for RR | Q value | P value for Q statistic | I2 |
Uptake of STI testing services | ||||||||
Any STI | RCT | 5 | 2.941 | 1.188 to 7.281 | 0.020 | 378.005 | 0.000 | 98.942 |
Multiple STIs (CT and NG) | RCT | 1 | 1.370 | 1.190 to 1.580 | – | – | – | – |
CT only | RCT | 4 | 3.567 | 1.096 to 11.608 | 0.035 | 294.647 | 0.000 | 98.982 |
Any STI—females only | RCT | 4 | 3.292 | 1.072 to 10.115 | 0.037 | 284.542 | 0.000 | 98.946 |
Any STI—males only | RCT | 3 | 6.900 | 1.721 to 27.656 | 0.006 | 62.182 | 0.000 | 96.784 |
CT only—males only | RCT | 3 | 6.900 | 1.721 to 27.656 | 0.006 | 62.182 | 0.000 | 96.784 |
Multiple STIs (CT and NG; NG and TV) | Obs | 2 | 2.990 | 0.426 to 20.978 | 0.271 | 21.427 | 0.000 | 95.333 |
CT only | Obs | 1 | 2.351 | 1.597 to 3.462 | – | – | – | – |
Case finding (proportion of positive test results) | ||||||||
Sensitivity analysis: denominator: those randomised/enrolled (intention to-treat) | ||||||||
CT only | RCT | 4 | 2.166 | 1.043 to 4.498 | 0.038 | 19.214 | 0.000 | 84.387 |
Any STIs (CT, NG and TV) | Obs | 1 | 1.122 | 0.449 to 2.802 | – | – | – | – |
CT only | Obs | 2 | 1.396 | 0.372 to 5.237 | 0.621 | 1.237 | 0.266 | 19.168 |
NG only | Obs | 2 | 0.978 | 0.249 to 3.835 | 0.974 | 0.071 | 0.789 | 0.000 |
TV (PCR) only | Obs | 2 | 1.590 | 0.43 to 5.878 | 0.487 | 0.001 | 0.981 | 0.000 |
TV (culture) only | Obs | 1 | 1.469 | 0.338 to 6.38 | – | – | – | – |
Sensitivity analysis: denominator: those who collected samples for STI testing (subgroup) | ||||||||
CT only | RCT | 4 | 0.718 | 0.585 to 0.882 | 0.002 | 1.343 | 0.719 | 0.000 |
Multiple STIs (CT and NG; NG and TV) | Obs | 2 | 1.378 | 0.582 to 3.264 | 0.466 | 3.886 | 0.049 | 74.269 |
CT only | Obs | 4 | 1.354 | 0.622 to 2.947 | 0.445 | 41.531 | 0.000 | 92.776 |
NG only | Obs | 3 | 0.939 | 0.558 to 1.577 | 0.811 | 2.272 | 0.321 | 11.956 |
TV (PCR) only | Obs | 2 | 0.791 | 0.208 to 3.004 | 0.730 | 1.041 | 0.308 | 3.926 |
TV (culture) only | Obs | 1 | 1.463 | 0.346 to 6.178 | – | – | – | – |
CT, Chlamydia trachomatis;NG, Neisseria gonorrhoeae;RR, risk ratio (pooled risk ratio if number of effect sizes>1);STI, sexually transmitted infection;TV, Trichomonas vaginalis.