Table 4

Interrupted time series analysis parameters of the volume of medicines in group 2 (‘three category’ market)

Active pharmaceutical ingredientReferentBioequivalents
Estimate95% CIP valueEstimate95% CIP value
Atorvastatin
 Level before the intervention (Embedded Image )401.61383.86 to 419.360.00406.58390.96 to 422.190.00
 Trend before the intervention (Embedded Image )−3.40−4.44 to −2.360.00−2.57−3.56 to −1.580.00
 Level change after the intervention (Embedded Image )−16.41−40.91 to 8.10.19−8.78−32.87 to 15.30.47
 Trend change after the intervention (Embedded Image )0.21−1.09 to 1.50.756.284.85 to 7.7 0.00
Cefadroxil
 Level before the intervention (Embedded Image )9.539.01 to 10.060.005.423.91 to 6.920.00
 Trend before the intervention (Embedded Image )−0.03−0.07 to 0.010.13−0.10−0.2 to 0.010.07
 Level change after the intervention (Embedded Image )−0.95−1.78 to −0.12 0.03 −0.94−1.6 to −0.27 0.01
 Trend change after the intervention (Embedded Image )−0.03−0.07 to 0.020.200.15−0.01 to 0.310.07
Doxycycline
 Level before the intervention (Embedded Image )3.632.76 to 4.490.0010.003.45 to 16.560.00
 Trend before the intervention (Embedded Image )0.04−0.03 to 0.120.26−0.10−0.82 to 0.630.79
 Level change after the intervention (Embedded Image )−2.16−3.62 to −0.7 0.00 −3.08−7.95 to 1.790.21
 Trend change after the intervention (Embedded Image )−0.09−0.17 to 0 0.04 0.12−1.08 to 1.320.84
Losartan
 Level before the intervention (Embedded Image )43.7734.18 to 53.350.00287.6671.39 to 503.930.01
 Trend before the intervention (Embedded Image )4.292.26 to 6.320.0016.73−2.09 to 35.540.08
 Level change after the intervention (Embedded Image )−22.68−27.15 to −18.22 0.00 −116.85−250.14 to 16.440.08
 Trend change after the intervention (Embedded Image )−7.62−11.22 to −4.02 0.00 −22.53−50.9 to 5.840.12
Ketoprofen
 Level before the intervention (Embedded Image )13.729.88 to 17.550.0035.3715.29 to 55.460.00
 Trend before the intervention (Embedded Image )−0.27−0.47 to −0.070.010.09−1.29 to 1.470.89
 Level change after the intervention (Embedded Image )−1.25−3.86 to 1.350.34−24.61−38.81 to −10.4 0.00
 Trend change after the intervention (Embedded Image )0.360.11 to 0.61 0.01 −0.36−2.12 to 1.40.68
Levothyroxine
 Level before the intervention (Embedded Image )3577.323480.93 to 3673.70.00186.45120.23 to 252.670.00
 Trend before the intervention (Embedded Image )17.3510.97 to 23.740.0010.854.66 to 17.040.00
 Level change after the intervention (Embedded Image )495.31328.38 to 662.25 0.00 42.70−71.59 to 156.980.46
 Trend change after the intervention (Embedded Image )−21.08−32.04 to −10.13 0.00 2.70−9.12 to 14.520.65
Prednisone
 Level before the intervention (Embedded Image )56.7043.44 to 69.960.00777.26614.23 to 940.290.00
 Trend before the intervention (Embedded Image )−1.72−2.49 to −0.940.0010.86−1.29 to 230.08
 Level change after the intervention (Embedded Image )−1.38−5.11 to 2.350.46−138.12−355.94 to 79.70.21
 Trend change after the intervention (Embedded Image )Product disappeared from the market after the intervention date−0.71−20.81 to 19.380.94
Metformin
 Level before the intervention (Embedded Image )498.85488.9 to 508.810.00342.48313.85 to 371.110.00
 Trend before the intervention (Embedded Image )−2.82−3.51 to −2.130.00−5.79−9.16 to −2.420.00
 Level change after the intervention (Embedded Image )−15.98−32.33 to 0.380.06−7.07−22.32 to 8.170.36
 Trend change after the intervention (Embedded Image )0.64−0.41 to 1.690.236.28−0.49 to 13.040.07
Clonazepam
 Level before the intervention (Embedded Image )202.84180.77 to 224.910.0072.8465.23 to 80.460.00
 Trend before the intervention (Embedded Image )−2.30−3.4 to −1.20.00−0.62−1.06 to −0.190.01
 Level change after the intervention (Embedded Image )0.94−31.9 to 33.790.95−0.67−7.38 to 6.040.84
 Trend change after the intervention (Embedded Image )1.970.62 to 3.31 0.00 0.34−0.12 to 0.790.15
  • We are considering a p value less than 0.05 as a statistically significant value. Bold means p value <0.05.

  • Units used in this analysis are the number of daily defined doses of the active pharmaceutical ingredients included.