Table 3

Interrupted time series analysis parameters of the volume of medicines in group 1 (‘two category’ market)

Active pharmaceutical ingredientReferentBioequivalents
Estimate95% CIP valueEstimate95% CIP value
Zidovudine
 Level before the intervention (Embedded Image )0.600.47 to 0.740.00Too few points before the intervention
 Trend before the intervention (Embedded Image )−0.01−0.02 to 00.22
 Level change after the intervention (Embedded Image )−0.26−0.66 to 0.140.19
 Trend change after the intervention (Embedded Image )Product disappeared from the market after the intervention date
Verapamil
 Level before the intervention (Embedded Image )0.660.62 to 0.7104.944.44 to 5.440.00
 Trend before the intervention (Embedded Image )−0.01−0.01 to −0.010.000.01−0.03 to 0.050.56
 Level change after the intervention (Embedded Image )−0.02−0.08 to 0.030.370.67−0.79 to 2.130.36
 Trend change after the intervention (Embedded Image )0.010.01 to 0.01 0.00 0.01−0.05 to 0.060.82
Ciclosporin
 Level before the intervention (Embedded Image )4.103.78 to 4.430.000.100.06 to 0.140.00
 Trend before the intervention (Embedded Image )0.00−0.02 to 0.020.920.020.02 to 0.020.00
 Level change after the intervention (Embedded Image )−0.29−0.53 to −0.04 0.02 −0.15−0.25 to −0.05 0.00
 Trend change after the intervention (Embedded Image )−0.01−0.03 to 0.010.450.010 to 0.010.07
Clomipramine
 Level before the intervention (Embedded Image )3.472.89 to 4.050.002.841.83 to 3.860.00
 Trend before the intervention (Embedded Image )−0.03−0.08 to 0.010.140.060.01 to 0.10.02
 Level change after the intervention (Embedded Image )−0.25−0.93 to 0.440.47−1.50−2.62 to −0.38 0.01
 Trend change after the intervention (Embedded Image )0.03−0.04 to 0.110.39−0.08−0.15 to −0.01 0.03
Tacrolimus
 Level before the intervention (Embedded Image )3.433.19 to 3.670.002.632.37 to 2.880.00
 Trend before the intervention (Embedded Image )0.040.03 to 0.050.000.010 to 0.020.16
 Level change after the intervention (Embedded Image )−0.09−0.4 to 0.230.580.07−0.21 to 0.350.63
 Trend change after the intervention (Embedded Image )−0.02−0.04 to 00.060.080.05 to 0.1 0.00
Acenocoumarol
 Level before the intervention (Embedded Image )109.28107.3 to 111.250.0030.8229.99 to 31.660.00
 Trend before the intervention (Embedded Image )−0.73−0.86 to −0.610.000.700.63 to 0.780.00
 Level change after the intervention (Embedded Image )−3.57−6.08 to −1.07 0.01 −0.62−2.79 to 1.550.57
 Trend change after the intervention (Embedded Image )−0.23−0.37 to −0.09 0.00 −0.16−0.28 to −0.03 0.01
Mycophenolate mofetil
 Level before the intervention (Embedded Image )3.693.37 to 40.003.312.88 to 3.730.00
 Trend before the intervention (Embedded Image )0.040.01 to 0.060.000.150.11 to 0.180.00
 Level change after the intervention (Embedded Image )0.28−0.19 to 0.750.240.38−0.35 to 1.120.30
 Trend change after the intervention (Embedded Image )−0.02−0.04 to 0.010.20−0.04−0.08 to 0 0.05
  • We are considering a p value less than 0.05 as a statistically significant value. Bold means p value <0.05.

  • Units used in this analysis are the number of daily defined doses of the active pharmaceutical ingredients included.