Active pharmaceutical ingredient | Referent | Bioequivalents | ||||

Estimate | 95% CI | P value | Estimate | 95% CI | P value | |

Total trend | ||||||

Level before the intervention ( ) | 4916.8 | 4786.3 to 5047.3 | 0.00 | 2142.8 | 1767.8 to 2517.7 | 0.00 |

Trend before the intervention ( ) | 10.1 | 1.65 to 18.61 | 0.02 | 28.08 | 0.8 to 55.4 | 0.04 |

Level change after the intervention ( ) | 518.5 | 302.78 to 734.2 |
0.00
| −58.3 | −722.3 to 605.7 | 0.86 |

Trend change after the intervention ( ) | −26.7 | −40.7 to −12.8 |
0.00
| −9.7 | −48.7 to 29.4 | 0.62 |

We are considering a p value less than 0.05 as a statistically significant value. Bold means p value <0.05.

Units used in this analysis are the number of daily defined doses of the active pharmaceutical ingredients included.