Antibody tests |
ELISA-binding assay: to detect LASV-binding antibodies and cross-reaction between clades (clades I–IV). ELISA-Competition: to define epitope specificity of binding antibodies to LASV GP. Neutralisation assay-LASV GPC: to detect antiviral neutralising antibodies/breadth of response (clades I–IV).
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T cell response tests |
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Immune profiling |
LASV-specific CD4 and CD8 T cells: to perform phenotypic and functional characterisation of T cells; to characterise vector-specific T cell response. Transcriptomics: gene expression profile characterisation of early immune responses and to identify potential effector function correlates.
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Antigen tests |
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Nucleic acid tests |
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