Six of the 10 WHO Blueprint priority diseases have significant diagnostic gaps
WHO Blueprint priority disease4 | Fatality rate | Recent outbreaks | Diagnostic need (red: critical, yellow: important; green: unaddressed)*5 | Situation overview5 |
CCHF | 10%–40%38 | Pakistan, 2010.39 |
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Filoviruses (Ebola and Marburg) | 24%–90%40 41 | West Africa, 2013–2016 and DRC 2017 and 2018 (Ebola).10 Uganda and Kenya, 2017 (Marburg).42 |
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Lassa fever | 1–15%43 | Annual recurring outbreaks in West Africa.44 |
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MERS-CoV | ~35%45 | Saudi Arabia, 2013–2018. South Korea, 2015.46 |
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SARS | ~10%47 | Global, 2003.47 |
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Nipah and henipaviral diseases | ~30%48 | Bangladesh, 2004.49
India, 2018.50 |
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Rift Valley fever | <1%51 | Republic of Niger, 2016.51 |
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Zika virus disease | Not fatal52 | South and North America, 2015–2016.29 |
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Disease X |
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*Red/critical: diagnostics needed but not currently available or validated; yellow/important: diagnostics currently under development; green/unaddressed: diagnostics available but may need improvement.
CCHF, Crimean-Congo haemorrhagic fever; EUAL, Emergency Use Assessment and Listing; MERS-CoV, Middle East respiratory syndrome coronavirus; POC, point of care; SARS, severe acute respiratory syndrome.