Table 2

Net DALYs averted at full and actual implementation levels

Intervention	(1)	(2)	(3)	(4)	(5)	(6)	(7)	(8)	(9)	(10)	(11)	(12)
Intervention	ICER ranking	ICER ($)	Pop. DALYs averted per 1000	Cases per annum (1000 s)	Actual imp. level	Total cost (full imp.; $1000s)	Total cost (actual imp.; $1000s)	Total DALYs averted (full imp.; 1000s)	Total DALYs averted (actual imp.; 1000s)	Net DALYs averted (full imp.; 1000s)	Net DALYs averted actual imp.; 1000s)	Financial value to the healthcare system of moving from actual to full imp. ($1000s)
Male circumcision	38	22	45	4073	12%	146 730	17 608	39 634	4756	25 423	3051	1 372 314
Isoniazid preventive therapy for HIV+ no (TB)	4	1	887	55	50%	80	40	1118	559	1098	549	33 673
First-line treatment for new TB cases for adults	5	3	393	14	64%	178	114	1045	669	1002	641	22 122
First-line treatment for new TB cases for children	7	3	393	12	64%	117	75	888	568	851	545	18 789
Clean practices and immediate essential newborn care (home)	9	3	368	671	0%	416	–	237	–	227	–	13 909
Management of pre-eclampsia (magnesium sulfate)	23	6	168	20	80%	45	36	535	428	483	386	5923
Voluntary counselling and testing	41	25	40	8031	15%	36 309	5446	167	25	98	15	5120
Rotavirus vaccine	22	6	177	651	0%	3097	–	88	–	80	–	4920
Households owning at least one ITN/LLIN	33	13	77	6752	56%	13 737	7706	228	128	180	101	4847
Malaria treatment: first trimester—uncomplicated	19	5	198	305	33%	1025	341	109	36	100	33	4087
PMTCT	27	11	94	53	55%	600	332	157	87	130	72	3561
Malaria treatment: uncomplicated—second line (adult, >36 kg)	13	4	260	4372	2%	1186	18	59	1	56	1	3354
Malaria treatment: uncomplicated—second line (adult, <36 kg)	14	4	260	4372	4%	593	21	59	2	56	2	3285
Labour and delivery management	28	11	89	918	65%	1281	833	170	111	139	91	2992
First-line treatment for retreatment TB cases for adults	6	3	393	2	65%	100	65	131	85	125	81	2688
Mass media	2	1	903	16 879	71%	7609	5402	150	107	148	105	2627
Malaria treatment: uncomplicated (adult, <36 kg)	11	4	260	4372	30%	3463	1039	59	18	56	17	2383
Interventions focused on men who have sex with men	48	51	20	34	5%	1256	63	232	12	40	2	2311
Antenatal care (four visits)	36	15	68	918	46%	11 230	5110	90	41	68	31	2289
First-line treatment for retreatment TB cases for children	8	3	393	2	65%	66	43	111	72	106	69	2283
Malaria treatment: second trimester—uncomplicated	20	5	198	305	67%	235	157	109	72	100	67	2047
Antenatal corticosteroids for preterm labour	40	25	40	165	0%	406	–	47	–	28	–	1718
Newborn sepsis— full supportive care	39	24	42	81	40%	417	167	60	24	37	15	1346
Cotrimoxazole for children	1	cost saving		127	13%	220	28	0	0	23	3	1208
Interventions focused on female sex workers	47	51	20	23	30%	655	197	161	48	28	8	1184
Vaginal delivery, skilled attendance	31	12	83	918	65%	5181	3368	67	43	54	35	1153
Malaria treatment: uncomplicated (adult, >36 kg)	12	4	260	4372	70%	4267	2987	59	41	56	39	1021
Tetanus toxoid (pregnant women)	24	7	149	918	84%	115	96	104	87	92	77	905
Malaria treatment: uncomplicated—second line (children, <15 kg)	17	4	260	1042	2%	35	1	14	0	13	0	799
Malaria treatment: uncomplicated—second line (children,>15 kg)	18	4	260	1042	4%	71	2	14	0	13	0	783
Schistosomiasis mass drug administration	42	29	35	389	13%	77	10	24	3	13	2	670
Vitamin A supplementation in pregnant women	25	7	140	124	65%	125	81	33	22	30	19	634
Malaria treatment: uncomplicated (children, >15 kg)	16	4	260	1042	40%	4768	1907	14	6	13	5	487
Antibiotics for pPRoM	45	40	25	64	30%	39	12	30	9	10	3	450
Maternal sepsis case management	44	39	26	64	0%	2731	–	20	–	7	–	449
Management of severe malnutrition (children)	46	50	20	51	80%	2437	1949	199	159	36	29	446
Isoniazid preventive therapy for children in contact with patients with TB	3	1	900	2	85%	7	6	45	38	44	38	408
Malaria treatment: uncomplicated (children, <15 kg)	15	4	260	1042	60%	4576	2746	14	8	13	8	325
Vaginal delivery, with complication	32	12	83	138	51%	804	410	10	5	8	4	242
Measles vaccine	26	9	106	651	99%	528	523	107	106	90	89	55
Management of obstructed labour	30	12	86	92	100%	1100	1100	2497	2497	2026	2026	–
Caesarean section	43	32	31	34	100%	672	672	327	327	157	157	–
Caesarean section (with complication)	29	12	86	5	100%	172	172	137	137	111	111	–
Pregnant women sleeping under an ITN	34	13	77	1469	100%	2990	2990	50	50	39	39	–
Under five children who slept under ITN/LLIN	35	13	77	494	100%	1006	1006	17	17	13	13	–
Blood safety	37	15	66	40	100%	1626	1626	12	12	9	9	–
Malaria treatment: pregnant women— complicated	21	5	198	16	100%	140	140	6	6	5	5	–
Case management of MDR TB cases	10	3	297	0	100%	12	12	5	5	5	5	–
Malaria treatment: pregnant women—complicated	21	5	198	16	100%	140	140	6	6	5	5	–
Caesarean section (with complication)	29	12	86	5	100%	172	172	137	137	111	111	–
Management of obstructed labour	30	12	86	92	100%	1100	1100	2497	2497	2026	2026	–
Pregnant women sleeping under an ITN	34	13	77	1469	100%	2990	2990	50	50	39	39	–
Under five children who slept under ITN/LLIN	35	13	77	494	100%	1006	1006	17	17	13	13	–
Blood safety	37	15	66	40	100%	1626	1626	12	12	9	9	–
Caesarean section	43	32	31	34	100%	672	672	327	327	157	157	–
IPT (pregnant women)	52	110	9	735	100%	35	35	0	0	−0	−0	–
GIT cancer	63	804	1	0	50%	3	1	0	0	−0	−0	−0
Cervical cancer (first line)	65	1087	1	2	50%	162	81	0	0	−0	−0	−0
Ischaemic heart disease	61	453	2	128	15%	4	1	0	0	−0	−0	−2
Diabetes, type I	57	296	3	23	15%	4304	646	0	0	−0	−0	−5
High cholesterol	49	68	15	223	1%	6703	67	1	0	−0	−0	−6
Basic psychosocial support, advice and follow-up, plus antiepileptic medication	50	82	12	506	3%	1266	38	1	0	−0	−0	−14
Treatment of depression	56	265	4	169	1%	332	3	0	0	−0	−0	−23
Diabetes, Type II	58	296	3	138	15%	4211	632	0	0	−1	−0	−30
Treatment of acute psychotic disorders	66	1646	1	169	1%	958	10	0	0	−1	−0	−42
Treatment of bipolar disorder	62	557	2	523	3%	10 362	321	0	0	−1	−0	−87
Treatment of schizophrenia	67	1646	1	2363	14%	13 413	1878	0	0	−10	−1	−512
Hypertension	55	159	6	846	10%	1338	134	44	4	−71	−7	−3912
ORS	54	153	7	8662	69%	937	647	147	102	−221	−152	−4197
Zinc (diarrhoea treatment)	51	99	10	7455	0%	1788	–	244	–	−150	–	−9207
Condoms	53	127	8	8031	47%	22 883	10 755	482	226	−517	−243	−16 813
ART for men	59	312	3	332	75%	21 159	15 961	1005	758	−4104	−3,096	−61 848
ART for women	60	312	3	509	82%	32 440	26 669	1541	1267	−6292	−5,173	−68 665
Paediatric ART	64	892	1	107	25%	7657	1892	1556	384	−21 074	−5,206	−973 334

ART, antiretroviral therapy; DALY, disability adjusted life year; GIT, gastrointestinal; ICER, incremental cost effectiveness ratio; IPT, intermittent preventive therapy; ITN, insecticide-treated bed net; LLIN, long-lasting insecticidal net; MDR, multidrug resistant; ORS, oral rehydration salts; PMTCT, prevention of mother to child transmission; pPRoM, preterm premature rupture of membranes; TB, tuberculosis.