Table 3

Gram-negative isolates resistance or intermediate-susceptibility to tested antimicrobials

OverallBeninCongoLiberiaMadagascarSierra LeoneTogoP value
Enterobacteriaceae 66216298871418391
 Ampicillin496 (74.9)146 (90.1)83 (84.7)35 (40.2)100 (70.9)65 (78.3)67 (73.6)<0.001
 Gentamicin172 (26.0)50 (30.9)26 (26.5)33 (37.9)26 (18.4)20 (24.1)17 (18.7)0.009
 Ceftriaxone162 (24.5)58 (35.8)25 (25.5)24 (27.6)23 (16.3)19 (22.9)13 (14.3)0.001
 Ciprofloxacin141 (21.3)47 (29.0)25 (25.5)22 (25.3)20 (14.2)17 (20.5)10 (11.0)0.003
 TMP/SMX406 (61.3)111 (68.5)57 (58.2)62 (71.3)77 (54.6)52 (62.7)47 (51.6)0.016
 Imipenem15 (2.3)1 (0.6)1 (1.0)2 (2.3)1 (0.7)4 (4.8)6 (6.6)0.013
 Amp+Gent146 (22.1)50 (30.9)26 (26.5)11 (12.6)25 (17.7)19 (22.9)15 (16.5)0.006
 Quin+Ceph3102 (15.4)41 (25.3)16 (16.3)14 (16.1)12 (8.5)11 (13.3)8 (8.8)0.001
 Resistant to ≥2 classes*159 (24.0)54 (33.3)21 (21.4)27 (31.0)24 (17.0)21 (25.3)12 (13.2)0.001
 Resistant to ≥3 classes*85 (12.8)32 (19.8)15 (15.3)11 (12.6)10 (7.1)8 (9.6)9 (9.9)0.023
 Resistant to ≥4 classes*2 (0.3)0 (0.0)0 (0.0)1 (1.1)0 (0.0)0 (0.0)1 (1.1)0.363
Pseudomonas spp287635242413059
 Gentamicin67 (23.3)10 (15.9)10 (19.2)11 (26.2)15 (36.6)4 (13.3)17 (28.8)0.097
 Ciprofloxacin48 (16.7)11 (17.5)6 (11.5)7 (16.7)9 (22.0)4 (13.3)11 (18.6)0.816
 Imipenem19 (6.6)1 (1.6)4 (7.7)3 (7.1)3 (7.3)2 (6.7)6 (10.2)0.559
Acinetobacter spp10226151422178
 Gentamicin26 (25.5)8 (30.8)5 (33.3)5 (35.7)4 (18.2)1 (5.9)3 (37.5)0.278
 Ciprofloxacin27 (26.5)10 (38.5)3 (20.0)2 (14.3)2 (9.1)7 (41.2)3 (37.5)0.105
 TMP/SMX60 (58.8)14 (53.8)8 (53.3)10 (71.4)12 (54.5)11 (64.7)5 (62.5)0.873
 Imipenem2 (2.0)0 (0.0)0 (0.0)0 (0.0)2 (9.1)0 (0.0)0 (0.0)0.191
  • Presented as number (%).

  • P values from the Fisher exact test.

  • *Antimicrobial classes defined as third-generation cephalosporins, aminoglycosides, fluoroquinolones and carbapenems.

  • Amp+Gent, Ampicillin + Gentamicin; Quin+Ceph3, Quinolone + third-generation cephalosporin; TMP/SMX, trimethoprim/sulfamethoxazole.