Overall disease severity of hand, foot and mouth disease (HFMD)
| Event | HFMD | Combined | EV-A71 | |||
| Rate | 95% CI | Rate | 95% CI | Rate | 95% CI | |
| Mortality (per 1000 CNS) | ||||||
| Pr(Death | CNS) | 50.2 | (29.2 to 73.5) | – | – | 104.7 | (49.0 to 177.8) |
| CNS (per 1000 hospitalisations) | ||||||
| Pr(CNS | Hospitalisation) | 186.7 | (66.6 to 314.9) | – | – | 368.8 | (258·. to 480.0) |
| Hospitalisation (per 1000 cases) | ||||||
| Pr(Hospitalisation | Case) | – | – | 60.2 | (28.2 to 148.6) | – | – |
| Mortality (per 1000 hospitalisations) | Product of mortality per CNS and CNS per hospitalisation | |||||
| 8.8 | (2.9 to 17.7) | 38.3 | (16.6 to 69.5) | |||
| Mortality (per 100 000 cases) | Product of mortality per hospitalisation and hospitalisation per case | |||||
| 52.3 | (24.4 to 92.7) | 230.1 | (74.9 to 670.1) | |||
| Symptoms (per 1000 infections) | ||||||
| Pr(Case | Infection) | ||||||
| Age 1 | – | – | 220.6 | (195.8 to 247.7) | – | – |
| Age 2 | – | – | 334.6 | (299.7 to 369.7) | – | – |
| Age 3 | – | – | 325.4 | (293.8 to 357.6) | – | – |
| Age 4 | – | – | 263.1 | (236 to 291.5) | – | – |
| Age 5 | – | – | 214.0 | (189.8 to 240.6) | – | – |
| Age 6 | – | – | 166.6 | (146.6 to 191) | – | – |
| Age 7 | – | – | 133.0 | (115.3 to 154.8) | – | – |
| Age 8 | – | – | 111.2 | (95.1 to 131.9) | – | |
| Age 9 | – | – | 100.3 | (84.8 to 121.2) | – | – |
| Infection (per 1000 person-years) | ||||||
| Pr(Infection) | ||||||
| Age 1 | 44.9 | (36.4 to 53.4) | – | – | 22.4 | (18.2 to 26.7) |
| Age 2 | 58.4 | (47.4 to 69·5) | – | – | 29.2 | (23.7 to 34.7) |
| Age 3 | 49.0 | (39.8 to 58.3) | – | – | 24.5 | (19.9 to 29.1) |
| Age 4 | 34.3 | (27.9 to 40.8) | – | – | 17.2 | (13.9 to 20.4) |
| Age 5 | 24.3 | (19.8 to 28.9) | – | – | 12.2 | (9.9 to 14.5) |
| Age 6 | 16.5 | (13.4 to 19.7) | – | – | 8.3 | (6.7 to 9.8) |
| Age 7 | 11.6 | (9.4 to 13.8) | – | – | 5.8 | (4.7 to 6.9) |
| Age 8 | 8.5 | (6.9 to 10.2) | – | – | 4.3 | (3.5 to 5.1) |
| Age 9 | 6.8 | (5.5 to 8.1) | – | – | 3.4 | (2.8 to 4.1) |
CNS, central nervous system.