Treatment groups | Adjusted OR* 95% CI p Value between | ||||
---|---|---|---|---|---|
A-HPF n=285 | RUTF-C n=280 | RUTF-L n=290 | RUTF-C and A-HPF | RUTF-L and A-HPF | |
Primary outcome | |||||
Recovered by 16 weeks | 122 (42.8) | 133 (47.5) | 165 (56.9) | 1.28 (0.90 to 1.82) p=0.164 | 1.71 (1.20 to 2.43) p=0.003 |
Secondary outcomes | |||||
Weight gain in g/kg/day of baseline weight | Adjusted difference | ||||
Mean (SD) | 2.64 (3.47) | 3.05 (3.41) | 3.52 (3.92) | 0.44 (−0.16 to 1.02) p=0.148 | 0.89 (0.30 to 1.48) p=0.003 |
Median (IQR) | 1.30 (0.80–3.02) | 1.61 (0.86–4.03) | 1.96 (0.93–4.77) | ||
Time to recovery (week) in children who recovered during the treatment phase | |||||
Mean (SD) | 7.12 (4.54) | 5.91 (4.03) | 6.05 (4.00) | −1.34 (−2.36 to −0.31) p=0.011 | −1.17 (−2.16 to −0.17) p=0.021 |
Median (IQR) | 6 (3–10) | 5 (3–8) | 5 (3–9) | ||
Children died | 0 | 2 | 1 | ||
Adjusted OR* 95% CI | |||||
Children hospitalised | 30 (10.5) | 30 (10.7) | 22 (7.6) | 0.96 (0.55 to 1.67) p=0.884 | 0.72 (0.40 to 1.31) p=0.286 |
n=243 | n=235 | n=249 | |||
Children with diarrhoea† at any time during the treatment phase | 101 (41.6) | 92 (39.2) | 109 (43.8) | 0.94 (0.62 to 1.42) p=0.773 | 1.19 (0.79 to 1.78) p=0.413 |
Children with ALRI‡ at any time during the treatment phase | 38 (15.6) | 24 (10.2) | 35 (14.1) | 0.59 (0.34 to 1.04) p=0.069 | 0.84 (0.50 to 1.41) p=0.506 |
Children with fever§ at any time during the treatment phase | 162 (66.7) | 142 (60.4) | 144 (57.8) | 0.74 (0.50 to 1.11) p=0.151 | 0.69 (0.46 to 1.02) p=0.062 |
All values are n (%) unless otherwise indicated.
*Generalised Linear Model (GLM) model sex, WHZ at enrolment, family structure, age at enrolment, maternal education, religion, caste, site and peer support.
†Diarrhoea: passage of ≥3 loose or watery stools in a 24-hour period.
‡ALRI: presence of cough or difficult breathing and either fast breathing or lower chest indrawing.
§Fever as reported by caregiver.
A-HPF, micronutrient-enriched (augmented) energy-dense home-prepared foods; ALRI, acute lower respiratory tract infection; RUTF-C, centrally produced ready-to-use therapeutic food; RUTF-L, locally prepared ready-to-use therapeutic food; WHZ, weight-for-height Z-score.