RT Journal Article SR Electronic T1 Threats by artificial intelligence to human health and human existence JF BMJ Global Health JO BMJ Global Health FD BMJ Publishing Group Ltd SP e010435 DO 10.1136/bmjgh-2022-010435 VO 8 IS 5 A1 Frederik Federspiel A1 Ruth Mitchell A1 Asha Asokan A1 Carlos Umana A1 David McCoy YR 2023 UL http://gh.bmj.com/content/8/5/e010435.abstract AB While artificial intelligence (AI) offers promising solutions in healthcare, it also poses a number of threats to human health and well-being via social, political, economic and security-related determinants of health. We describe three such main ways misused narrow AI serves as a threat to human health: through increasing opportunities for control and manipulation of people; enhancing and dehumanising lethal weapon capacity and by rendering human labour increasingly obsolescent. We then examine self-improving ‘artificial general intelligence’ (AGI) and how this could pose an existential threat to humanity itself. Finally, we discuss the critical need for effective regulation, including the prohibition of certain types and applications of AI, and echo calls for a moratorium on the development of self-improving AGI. We ask the medical and public health community to engage in evidence-based advocacy for safe AI, rooted in the precautionary principle.There are no data in this work.