TY - JOUR T1 - Availability, scope and quality of monkeypox clinical management guidelines globally: a systematic review JF - BMJ Global Health JO - BMJ Global Health DO - 10.1136/bmjgh-2022-009838 VL - 7 IS - 8 SP - e009838 AU - Eika Webb AU - Ishmeala Rigby AU - Melina Michelen AU - Andrew Dagens AU - Vincent Cheng AU - Amanda M Rojek AU - Dania Dahmash AU - Susan Khader AU - Keerti Gedela AU - Alice Norton AU - Muge Cevik AU - Erhui Cai AU - Eli Harriss AU - Samuel Lipworth AU - Robert Nartowski AU - Helen Groves AU - Peter Hart AU - Lucille Blumberg AU - Tom Fletcher AU - Shevin T Jacob AU - Louise Sigfrid AU - Peter W Horby Y1 - 2022/08/01 UR - http://gh.bmj.com/content/7/8/e009838.abstract N2 - Background Monkeypox (MPX) is an important human Orthopoxvirus infection. There has been an increase in MPX cases and outbreaks in endemic and non-endemic regions in recent decades. We appraised the availability, scope, quality and inclusivity of clinical management guidelines for MPX globally.Methods For this systematic review, we searched six databases from inception until 14 October 2021, augmented by a grey literature search until 17 May 2022. MPX guidelines providing treatment and supportive care recommendations were included, with no exclusions for language. Two reviewers assessed the guidelines. Quality was assessed using the Appraisal of Guidelines for Research and Evaluation II tool.Results Of 2026 records screened, 14 guidelines were included. Overall, most guidelines were of low-quality with a median score of 2 out of 7 (range: 1–7), lacked detail and covered a narrow range of topics. Most guidelines focused on adults, five (36%) provided some advice for children, three (21%) for pregnant women and three (21%) for people living with HIV. Treatment guidance was mostly limited to advice on antivirals; seven guidelines advised cidofovir (four specified for severe MPX only); 29% (4/14) tecovirimat, and 7% (1/14) brincidofovir. Only one guideline provided recommendations on supportive care and treatment of complications. All guidelines recommended vaccination as post-exposure prophylaxis (PEP). Three guidelines advised on vaccinia immune globulin as PEP for severe cases in people with immunosuppression.Conclusion Our results highlight a lack of evidence-based clinical management guidelines for MPX globally. There is a clear and urgent need for research into treatment and prophylaxis including for different risk populations. The current outbreak provides an opportunity to accelerate this research through coordinated high-quality studies. New evidence should be incorporated into globally accessible guidelines, to benefit patient and epidemic outcomes. A ‘living guideline’ framework is recommended.PROSPERO registration number CRD42020167361.Data are available upon reasonable request. All data generated or analyzed during this study are available on reasonable requests from the corresponding author. ER -