PT - JOURNAL ARTICLE AU - Liyanage, Thaminda AU - Toyama, Tadashi AU - Hockham, Carinna AU - Ninomiya, Toshiharu AU - Perkovic, Vlado AU - Woodward, Mark AU - Fukagawa, Masafumi AU - Matsushita, Kunihiro AU - Praditpornsilpa, Kearkiat AU - Hooi, Lai Seong AU - Iseki, Kunitoshi AU - Lin, Ming-Yen AU - Stirnadel-Farrant, Heide A. AU - Jha, Vivekanand AU - Jun, Min TI - Prevalence of chronic kidney disease in Asia: a systematic review and analysis AID - 10.1136/bmjgh-2021-007525 DP - 2022 Jan 01 TA - BMJ Global Health PG - e007525 VI - 7 IP - 1 4099 - http://gh.bmj.com/content/7/1/e007525.short 4100 - http://gh.bmj.com/content/7/1/e007525.full SO - BMJ Global Health2022 Jan 01; 7 AB - Introduction The burden of chronic kidney disease (CKD) is growing rapidly around the world. However, there is limited information on the overall regional prevalence of CKD, as well as the variations in national prevalence within Asia. We aimed to consolidate available data and quantify estimates of the CKD burden in this region.Methods We systematically searched MEDLINE, Embase and Google Scholar for observational studies and contacted national experts to estimate CKD prevalence in countries of Asia (Eastern, Southern and South Eastern Asia). CKD was defined as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 or the presence of proteinuria. For countries without reported data, we estimated CKD prevalence using agglomerative average-linkage hierarchical clustering, based on country-level risk factors and random effects meta-analysis within clusters. Published CKD prevalence data were obtained for 16 countries (of the 26 countries in the region) and estimates were made for 10 countries.Results There was substantial variation in overall and advanced (eGFR <30 mL/min/1.73 m2) CKD prevalence (range: 7.0%–34.3% and 0.1%–17.0%, respectively). Up to an estimated 434.3 million (95% CI 350.2 to 519.7) adults have CKD in Asia, including up to 65.6 million (95% CI 42.2 to 94.9) who have advanced CKD. The greatest number of adults living with CKD were in China (up to 159.8 million, 95% CI 146.6 to 174.1) and India (up to 140.2 million, 95% CI 110.7 to 169.7), collectively having 69.1% of the total number of adults with CKD in the region.Conclusion The large number of people with CKD, and the substantial number with advanced CKD, show the need for urgent collaborative action in Asia to prevent and manage CKD and its complications.All data relevant to the study are included in the article or uploaded as online supplemental information. All data generated or analysed during this study are included in this article and its online supplemental information files. Restrictions apply to the availability of individual participant data collected and used by agreement of the Asian Renal Collaboration for the current study, and so are not publicly available.